Ngf Antibody, Biotin conjugated

Code CSB-PA16859D0Rb
Size US$299
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Product Details

Full Product Name Rabbit anti-Rattus norvegicus (Rat) Ngf Polyclonal antibody
Uniprot No. P25427
Target Names Ngf
Alternative Names Ngf antibody; Ngfb antibody; Beta-nerve growth factor antibody; Beta-NGF antibody
Raised in Rabbit
Species Reactivity Rat
Immunogen Recombinant Rat Beta-nerve growth factor protein (124-241AA)
Immunogen Species Rattus norvegicus (Rat)
Conjugate Biotin
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI.
Gene References into Functions
  1. proinflammatory cytokines suppressed the TGFbetamediated expression of NGF in PDLderived fibroblasts through the inactivation of TGFbetainduced Smad2/3 and p38 MAPK signaling. PMID: 29901090
  2. Impairments in the extracellular maturation of proNGF are sufficient to cause a somatodendritic retrograde degeneration o fdegeneration of basal forebrain cholinergic neurons. PMID: 29609077
  3. McGill APP transgenic rats exhibit differential dysregulation in NGF and BDNF neurotrophins. At early stages, intraneuronal Abeta leads to significant reductions in BDNF mRNA expression, which correlate with learning and memory deficits. At later stages, deficits in the NGF metabolic pathway could explain the paradoxical upregulation of proNGF in the absence of changes in NGF mRNA. PMID: 28865749
  4. p75NTR is sufficient to mediate the modulation of myogenic cells differentiation by NGF in terms of structural, metabolic and functional changes. PMID: 29202822
  5. NGF protects GECs against IND-induced injury. Mitochondria are major targets of both INDO-induced injury and NGF afforded protection of GECs. TrkA expression in the mitochondria of GECs indicates that the protection afforded by NGF is partly mediated by its direct action on mitochondria. NGF prevents MMP depolarization and increases expression of IGF-1 protein in GECs. PMID: 28843696
  6. The results suggest that NGF is a prominent hyperalgesic mediator in the trigeminal system and plays a role in trigeminal neuropathic pain PMID: 27392124
  7. Early and late behavioral changes in sciatic nerve injury may be modulated by nerve growth factor and substance P in rats PMID: 28685530
  8. A higher level of nerve growth factor in the early days post-transvaginal mesh implantation is associated with a shorter voiding interval and a smaller bladder capacity, which represents abnormal lower urinary tract symptoms following transvaginal mesh implantation. PMID: 27762470
  9. Findings might aid in identifying effective treatment windows for nerve growth factor (NGF)-based strategies to counteract retinal and/or optic-nerve degeneration. PMID: 28067793
  10. The aim of our study was to investigate the influence of two mild stressors, acute and chronic exposure to forced swim (FS) or high-light open field (HL-OF), on neurons containing NGF. PMID: 27978417
  11. This work sheds light on the role of miR-132 in bladder overactivity, bladder hypertrophy, NGF signaling and expression of inflammatory mediators. Findings demonstrate that aberrant expression of NGF and miR-132 is involved in voiding dysfunctions. PMID: 27789288
  12. Data indicate the effects of vitamin B12 and omega-3 fatty acid supplementation across three consecutive generations on brain neurotrophins like brain derived neurotrophic factor (BDNF); nerve growth factor (NGF) and cognitive performance in the third generation male offspring. PMID: 27569259
  13. This study demonstrated that Age-dependent changes in the density of NGF-ir neurons in stressed rats are probably caused by ageing processes and they may point to dysregulation of excitatory control exerted by the amygdala. PMID: 26724365
  14. Data indicate that nerve growth factor precursors and nerve growth factor (ProNGF and NGF) and the downstream effector proteins play an important role in the growth, differentiation, and apoptosis of oligodendrocyte (OLG). PMID: 26681653
  15. NGF in the facet joint contributes to the development of injury-induced joint pain. Localized blocking of NGF signaling in the joint may provide potential treatment for joint pain. PMID: 26521746
  16. This study deminstrated that elevated NGF after peripheral nerve injury induces neurite sprouting and the formation of synapse-like structures within the contralateral DRG, leading to the development of chronic mirror-image pain. PMID: 26121254
  17. Results suggest the induction of NGF represents an adaptive response against immune-mediated neuroinflammation in the dorsal root ganglia and spinal cord that likely contributes to the experimental autoimmune encephalomyelitis attenuation PMID: 25801841
  18. elevation of plasma norepinephrine in neonatal colonic inflammation induces NGF expression in the gastric fundus. PMID: 26608656
  19. NGF acts directly on photoreceptors survival and prevents photoreceptor degeneration. PMID: 25897972
  20. Identify nerve growth factor as a binding partner for MOG and demonstrate that this interaction is capable of sequestering NGF from TrkA-expressing neurons to modulate axon growth and survival. PMID: 26347141
  21. Let-7 microRNAs regulate peripheral nerve regeneration by targeting nerve growth factor. PMID: 25394845
  22. Ginger extract has a synaptogenic effect via NGF-induced ERK/CREB activation, resulting in memory enhancement. PMID: 25049196
  23. Chronic heart failure impairs the expression of nerve growth factor in the sympathetic and sensory nerves. PMID: 24913185
  24. Vibration significantly increases total-NGF mRNA in interverterbal discs. Protein expression of BDNF increases by nearly 10-fold, especially in the inner annulus fibrosus and nucleus pulposus. PMID: 24921856
  25. NGF exhibits anti-oxidative and hepatoprotective effects and is suggested to be therapeutically applicable in treating cholestatic liver diseases. PMID: 25397406
  26. Activation of microtubule dynamics increases neuronal growth via the NGF- and Galpha s-mediated signaling pathways. PMID: 25691569
  27. NGF was increased 12, 24, and 48 hours in hippocampus after sepsis induction PMID: 24978930
  28. Findings revealed that NGF may play a pivotal role of anti-apoptosis in spinal cord neurons through retrograde transport of NF-kappaB in Schwann cells following sciatic nerve injury in rats PMID: 24620979
  29. Maternal separation decreased NGF levels in the hippocampus which was reversed with methamphetamine. PMID: 24407463
  30. the level of NGF expression did not display a meaningful change throughout the immobilization period PMID: 24154957
  31. Spinal nerve afferents are important in sustaining and up-regulating the expression of NGF in the sensory neurons innervating the heart in acute myocardial infarction. PMID: 24508054
  32. NGF played an important role in the activation of Akt and subsequent up-regulation of BDNF in the sensory neurons in visceral inflammation such as cystitis. PMID: 24303055
  33. The temporal mismatch in behaviour, skin [NGF] and phenotypic changes in sensory nerve fibres indicate that increased [NGF] does not cause hyperalgesia after partial mental nerve injury. PMID: 24380503
  34. Using gene expression as a functional read-out, our data demonstrate that the relative availability of NGF and proNGF in vivo might modulate the biological outcome of these ligands. PMID: 24713110
  35. The synergistic effects of grafting both NGF and GRGD ligands to PCL-CS scaffolds on the growth and differentiation of PC12 cells provide a new biomaterial for neural tissue engineering. PMID: 23468336
  36. Denervation causes age-dependent increases in NGF in the VP, which is a potential mechanism by which the autonomic nervous system may regulate prostate growth and lead to BPH/LUTS PMID: 23872662
  37. proBDNF accumulated in the hippocampus of aged rats. PMID: 23255148
  38. The effects of acute and chronic administration of branched-chain amino acids on protein levels and mRNA expression of nerve growth factor, was investigated. PMID: 23559405
  39. Suggest that nerve growth factor, which is elevated in the failing human heart, causes hypertrophy of neurons in cardiac ganglia. PMID: 23959444
  40. Hyperosmolarity induces apoptosis of pHCECs by activating JNK signaling. PMID: 24327613
  41. Environmental enrichment improves memory and increases nerve growth factor (NGF) concentration in the dentate gyrus. PMID: 23460346
  42. NGF contributes to the repair of nerve tissue and improves pain-related behavior after inferior alveolar nerve injury. PMID: 23190308
  43. Long-term casting induced heat hyperalgesia, and up-regulation and phenotypic change of NGF in dorsal root ganglia PMID: 23234417
  44. Data indicate that nerve growth factor (NGF) mRNA levels changed significantly during Leydig-cell regeneration in vivo. PMID: 23743199
  45. Upregulation of NGF in the amygdala promotes behavior of opioid reward and increases sensitivity to subsequent opioids. PMID: 22871918
  46. This study suggests that application of hADSCs with NGF-hydrogel on the CN might be a promising treatment for postprostatectomy ED. PMID: 22834730
  47. NGF increased expression of ASIC3 in DRG neurons. PMID: 22744968
  48. [REVIEW] Neuropathies and clinical presentations result from disruption of NGF signalling in hereditary sensory autonomic neuropathies (HSAN) type IV and HSAN type V. PMID: 23157347
  49. NGF gene expression is elevated during the whole course of cerebral concussion, especially in the early phase. PMID: 12857442
  50. There were much more Ngf-immunoreactive nerve cells expressed in the dorsal horn in sciatic nerve cryoneurolysis rats with hyperalgesia. PMID: 22580175
  51. Hormonal status led to significant differences in NGF protein expression in urethral epithelium and periurethral smooth muscle of female rats. PMID: 22532231
  52. expression of proteins associated with lysosomes and proteasomes were upregulated selectively in axons by NGF stimulation of the distal axons of sympathetic neurons PMID: 22411744
  53. In both ventricles, we observed a significant decrease in NGF expression from neonatal to young rats and a significant increase from young to old rats. The highest NGF amount in LV and RV was observed in neonatal rats. PMID: 21559866
  54. NGF enhanced the interaction between TrkA and microtubules in detergent-resistant membranes. PMID: 22496904
  55. Data confirmed a lower expression of beta-NGF in undescended testes than in the development of testis. PMID: 22490502
  56. NGF was expressed in the nasal mucosa of rats with depression. PMID: 22500463
  57. ProNGF expression increases following nerve injury in those cell types previously suggested to express it. PMID: 22233577
  58. Decreased NGF-dependent calcitonin production in dorsal root ganglia primary sensory neurons plays an important role in early vibration-induced pathological mechanisms. PMID: 21561603
  59. NGF expression levels in the prostate tissues of spontaneously hypertensive rats were markedly higher than in normotensive rats. PMID: 21961236
  60. NGF expression increased but M3 subtype muscarinic receptor expression decreased in the seminal vesicle of diabetic rats. PMID: 22141271
  61. Chronic failure of extracellular NGF maturation leads to a reduction in mature NGF levels, proNGF accumulation, cholinergic degeneration, and cognitive impairment. PMID: 22323714
  62. Increased extracellular NGF precursor levels following seizures are stabilized by altered MMP-7 enzymatic activity, leading to increased neuronal death via activation of p75(NTR). PMID: 22238106
  63. Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cell PMID: 22065583
  64. Cardiomyocytes control their local NGF milieu under conditions of high rate or irregular stimulation by activating two different signalling routes PMID: 21889978
  65. These findings emphasize a key role for nerve growth factor in maintaining neuronal excitability in chronic pancreatitis specifically via downregulation of A-type potassium currents by as yet unknown mechanisms. PMID: 22038828
  66. The spared nerve injury model discovers mechanisms linking reactive astrogliosis and perturbation of synaptic circuitry in the spinal cord, and how they correlate with alterations of endogenous NGF levels. PMID: 21111819
  67. NGF is closely related to increases in P2X(3) receptor expression and response under ischemic conditions leading to augmentation of the muscle reflex. PMID: 21642505
  68. Data suggest that NGF and proNGF activate distinct transcriptional programs and that the ratio of NGF to proNGF in vivo can profoundly influence the pattern of regulated mRNAs. PMID: 21677785
  69. These results suggest that treadmill exercise increases NGF PMID: 21207218
  70. Expression of NGF was greatly increased in the P. africanum group compared with that of the diabetic group. PMID: 20490673
  71. NGF affected intracellular localization of full-length Axl-eGFP and Tyro-3-eCFP in PC12 cells PMID: 21270900
  72. Cardiac sympathetic nerve density is regulated by the NGF expression in the heart; long-exposure of high plasma norepinephrine concentration causes myocardial NGF reduction following sympathetic fiber loss in animals with severe congestive heart failure. PMID: 20335077
  73. Both nerve growth factor and brain-derived growth factor prevent staurosporine-induced apoptotic morphology and caspase-3 activity by upregulating phosphorylation of the tropomyosin receptor kinase (Trk) receptor. PMID: 20644345
  74. trkA mRNA expression inversely correlates with p75 and NGF mRNA expression. CFA chronic inflammation evolves from inflammation to a small fibers sensory neuropathy and nerve growth factor (NGF) seems to play a role in both events PMID: 17952852
  75. respiratory syncytial virus infection after chronic nicotine exposure exerted an additive effect on NGF (nerve growth factor) expression resulting in exaggerated neurogenic airway inflammation PMID: 19824047
  76. Reactive oxygen species, Ki-Ras, and mitochondrial superoxide dismutase cooperate in nerve growth factor-induced differentiation of PC12 cells PMID: 20495008
  77. Results describe the effects of Semax administration on NGF and BDNF gene expression in rat hippocampus, frontal cortex, and retina. PMID: 19662538
  78. Ginseng total saponins can decrease the expression of NGF in ovary tissue in rats with polycystic ovaries. PMID: 18601856
  79. The changes of NGF expression following diffuse axonal injury may be applied to estimate the post-injury time interval of the brain. PMID: 18709849
  80. 2,5-hexanedione could increase NGF levels in sciatic nerve of rats in a time- and dose-dependent effect. PMID: 20388358
  81. NGF serves in maintenance of bradykinin by sensitizing muscle C-fiber receptors to mechanical stimulation. PMID: 20220009
  82. NGF, by enhancing Mos in late spermatocytes, is one of the intra-testicular factors which adjusts the number of round spermatids that can be supported by Sertoli cells PMID: 19802389
  83. NGF in the regenerative phenomena subsequent to a Trypanosoma cruzi-induced myocarditis able to damage sympathetic nerve endings, with preservation of preterminals and nerve trunks PMID: 16854632
  84. PI3K might contribute to the nuclear translocation of Akt, and Akt phosphorylation is essential for its nuclear retention under NGF stimulation conditions PMID: 16956580
  85. Nerve growth factor beta should participate in an auto/paracrine pathway of regulation of the second meiotic division of rat spermatocytes in vivo. PMID: 17013810
  86. exon 1-9 contributes to changes in total BDNF levels and may play an important role in the acute response of dorsal root ganglion to NGF PMID: 17764660
  87. ONO-2235 improved bladder emptying function and restored the decreased genetic expression of bladder nerve growth factor and neurotrophin receptor p75 in 9-week streptozotocin induced diabetic rats PMID: 17870109
  88. investigated the early signalling events that contribute to NGF and laminin-induced neurite growth. PMID: 17999938
  89. Data show that the synergistic effect of histamine and IL-6 on NGF secretion from cultured astrocytes is evoked by histamine stimulation of IL-6 secretion via a H1-receptor-PKC-MAPK signalling pathway. PMID: 18345501
  90. The results showed that chronic administration of antipsychotics did not modify BDNF and NGF levels in rat hippocampus, suggesting that their therapeutic properties are not mediated by stimulation of these neurotrophins. PMID: 18496748
  91. These findings indicate that Hsp25 is not required for NGF-induced neurite outgrowth in PC12 cells and is not responsible for the heat shock-enhancement of NGF-induced neurite elongation. PMID: 18561899
  92. The present study pinpoints loop II of NGF to be an important structural determinant for NGF biological activity mediated by TrkA receptor. PMID: 18635195
  93. Nerve growth factor promotes development of glucose-induced insulin secretion in rat neonate pancreatic beta cells by modulating calcium channels PMID: 18690044
  94. Data show that elevated intraocular pressure significantly impairs the presence of NGF in the optic nerve of glaucomatous eye. PMID: 18817846
  95. study identified 5 new NGF-responsive immediate-early genes including Cited2, Klf4, Maff, Klf10 or Tieg and Atf3 PMID: 19013137
  96. Most cardiac ganglion neurons are shown to express nerve growth factor (NGF) transcripts; 40% contained mature and 47% NGF precursor. PMID: 19019738
  97. Data show that the 22-24 kDa NGF species in the superior cervical ganglion are significantly reduced following axotomy. PMID: 19100726
  98. Nerve growth factor is upregulated following muscle incision and contributes to pain behavior. PMID: 19104181
  99. Our results indicate that the observed heat hyperalgesia is not dependent on NGF-induced changes in SP content and release from primary sensory neurons. PMID: 19125373
  100. Mechanical stretch and alpha-1-adrenergic stimulation contribute to a decrease of cardiomyocyte NGF expression via the calcineurin-NFAT pathway. PMID: 19150448

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Subcellular Location Secreted
Protein Families NGF-beta family
Database Links

KEGG: rno:310738

STRING: 10116.ENSRNOP00000022200

UniGene: Rn.22168

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