PA Antibody, FITC conjugated

Datasheet
Code CSB-PA395880EC01ILR
Size US$299
Uniprot No. A4U6V9
Protocols ELISA Protocol
Immunogen Recombinant Influenza A virus Polymerase acidic protein (1-716AA)
Raised in Rabbit
Species Reactivity Influenza A virus
Tested Applications ELISA
Relevance Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity. In addition of its function in viral transcription, PA also plays an essential role in viral RNA synthesis and promotes the formation of the trimeric polymerase complex.
Form Liquid
Conjugate FITC
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2), PA
Immunogen Species Influenza A virus (strain A/USA:Huston/AA/1945 H1N1)
Research Area Others
Target Names PA
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.
Subcellular Location Host cytoplasm, Host nucleus
Protein Families Influenza viruses PA family

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