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| Code | CSB-PA017451KA01HU |
| Product Type | Rabbit Anti Human PolyClonal Antibody |
| Size | US$398 |
| Uniprot No. | O60260 |
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| Protocols | ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol |
| Immunogen | Recombinant protein of Human PARK2 |
| Raised in | Rabbit |
| Species Reactivity | Human,Mouse,Rat |
| Tested Applications | ELISA,WB,IHC;WB:1:500-1:2000,IHC:1:50-1:200 |
| Relevance | Parkin is a protein of 465 amino acids with an amino-terminal ubiquitin domain and a carboxy-terminal RING-box. In the case of autosomal recessive juvenile Parkinsonism (AR-JP), deletions have been found in the gene on chromosome 6 encoding the protein Parkin. |
| Storage Buffer | Store at -20°C or -80°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Purification Method | Affinity purification |
| Isotype | IgG |
| Alias | PARK2;AR-JP;LPRS2;PDJ;PRKN;Parkin |
| Immunogen Species | Homo sapiens (Human) |
| Research Area | Apoptosis |
| Intended Use | For research use only. Not for human, diagnostic or therapeutic use. |
| Target Names | PRKN |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Target Details | The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. |
| HGNC | 28442 |
| RGD | 1311045 |
| MGI | 1914018 |
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| Function | Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2 |
| Involvement in disease | Parkinson disease (PARK); Parkinson disease 2 (PARK2) |
| Subcellular Location | Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion |
| Protein Families | RBR family, Parkin subfamily |
| Tissue Specificity | Highly expressed in the brain including the substantia nigra. Expressed in heart, testis and skeletal muscle. Expression is down-regulated or absent in tumor biopsies, and absent in the brain of PARK2 patients. Overexpression protects dopamine neurons fro |
| Database Links |
HGNC: 8607 OMIM: 168600 KEGG: hsa:5071 STRING: 9606.ENSP00000355865 UniGene: Hs.132954 |
| Pathway |
Protein processing in endoplasmic reticulum
Ubiquitin mediated proteolysis |
PRKN Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA017451LA01HU | PRKN Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA017451LB01HU | PRKN Antibody, HRP conjugated | Human | ELISA |
| CSB-PA017451LC01HU | PRKN Antibody, FITC conjugated | Human | ELISA |
| CSB-PA017451LD01HU | PRKN Antibody, Biotin conjugated | Human | ELISA |
PRKN Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA076233 | PARK2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA003708 | PARK2 Antibody | Human | WB,IHC,ELISA |
| CSB-PA020235 | Phospho-PARK2 (S131) Antibody | Human | WB,IHC,ELISA |
| CSB-PA020236 | PARK2 Antibody | Human,Mouse,Rat | WB,IHC,IF,ELISA |
PRKN Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-BP017451HUb1 | Recombinant Human E3 ubiquitin-protein ligase parkin(PRKN) | Baculovirus |
| CSB-YP017451HU CSB-MP017451HU |
Recombinant Human E3 ubiquitin-protein ligase parkin(PRKN) | Yeast Mammalian cell |
| CSB-EP017451HU | Recombinant Human E3 ubiquitin-protein ligase parkin(PRKN) | E.coli |
| CSB-BP017451HU | Recombinant Human E3 ubiquitin-protein ligase parkin(PRKN) | Baculovirus |
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