POU2F1 Antibody, HRP conjugated

Datasheet
Code CSB-PA018393LB01HU
Size US$299
Uniprot No. P14859
Protocols ELISA Protocol
Immunogen Recombinant Human POU domain, class 2, transcription factor 1 protein (442-743AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.
Form Liquid
Conjugate HRP
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1), POU2F1, OCT1 OTF1
Immunogen Species Homo sapiens (Human)
Research Area Epigenetics and Nuclear Signaling
Target Names POU2F1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.
Subcellular Location Nucleus
Protein Families POU transcription factor family, Class-2 subfamily
Tissue Specificity Ubiquitous. Isoform 2 is lymphocyte-specific.
Database Links

HGNC: 9212

OMIM: 164175

KEGG: hsa:5451

STRING: 9606.ENSP00000356840

UniGene: Hs.283402

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