RRAS Antibody, Biotin conjugated

Code CSB-PA020513PD01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) RRAS Polyclonal antibody
Uniprot No. P10301
Target Names RRAS
Alternative Names Oncogene RRAS antibody; p23 antibody; R Ras antibody; Ras related Protein antibody; Ras related protein R Ras antibody; Ras-related protein R-Ras antibody; related RAS viral (r ras) oncogene homolog antibody; RRAS antibody; RRAS_HUMAN antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Peptide sequence from Human Ras-related protein R-Ras protein (7-23AA)
Immunogen Species Homo sapiens (Human)
Conjugate Biotin
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Regulates the organization of the actin cytoskeleton
Gene References into Functions
  1. R-Ras activation is associated melanoma tumorigenesis. PMID: 26993606
  2. this study identified potential biochemical players involved in distant recurrence and indicates that R-Ras and Transgelin are potential post-surgical prognostic biomarkers for Stage III colorectal cancer PMID: 27270312
  3. RRAS is a key regulator of miR-34/449 promotion of actin network formation during multiciliogenesis. PMID: 26381333
  4. Evidence is provided of a functional link between RRAS and MAPK signalling and reveal an unpredicted role of enhanced RRAS function in human disease. PMID: 24705357
  5. Girdin regulates the trafficking of VE-cadherin in synergy with R-Ras. PMID: 25869066
  6. phosphorylation of ORP3 controls its association with VAPA. Furthermore, ORP3-VAPA complexes stimulate R-Ras signaling. PMID: 25447204
  7. Contradicting the positive association reported in previous studies, our results indicate that R-Ras activation may negatively regulate the transformation of breast epithelial cells. PMID: 24700169
  8. A polymorphism linked to RRAS, SCAF1, IRF3 and BCL2L12 genes is associated with cirrhosis in hepatitis C virus carriers. PMID: 24131527
  9. Patients with gemistocytic astrocytomas with an RRAS deletion tend to have shorter survival rates than those without deletion. PMID: 25192052
  10. These data suggest that pharmacological inhibition of RRAS signaling may confer therapeutic benefit in Huntington's disease. PMID: 23209424
  11. These findings identify R-Ras as a critical regulator of vessel integrity and function during tumor vascularization. PMID: 22897853
  12. Maintaining endothelial barrier function is dependent upon active R-Ras and association between R-Ras and FLNa. PMID: 21660952
  13. Data suggest that the RRAS gene is an important regulatory module in the pathogenesis of biliary atresia (BA), which may serve as a novel prognostic marker for BA. PMID: 21390152
  14. data support a model in which R-Ras functionally associates with FLNa and thereby regulates integrin-dependent migration PMID: 20585650
  15. Sema3E acts on plexin D1 to initiate a two-pronged mechanism involving R-Ras inactivation and Arf6 stimulation, which affect the status of activation of integrins and their intracellular trafficking, respectively. PMID: 20385769
  16. study of the potential contribution in generating of estrogen-independence in MCF-7 cells PMID: 12386818
  17. the oncogene R-Ras promotes tumor growth of cervical epithelial cells and increases their migration potential over collagen through a pathway that involves PI 3-K. PMID: 12548599
  18. activation of R-Ras promotes the formation of focal adhesions and a spread cell shape PMID: 12890755
  19. Plexin-B1 mediates Sema4D-induced repulsive axon guidance signaling by acting as a GTPase activating protein for R-Ras PMID: 15297673
  20. R-Ras plays a key role in cell migration by locally regulating the switch from Rac to Rho activity after membrane protrusion and adhesion PMID: 15525681
  21. GPCRs rapidly activate R-Ras; R-Ras activation by the GPCRs is apparently directly induced by cyclic AMP-regulated Epac proteins; and activated R-Ras specifically controls GPCR-mediated phospholipase D stimulation PMID: 16754664
  22. These findings show that R-Ras activity mediates inhibition of insulin signaling associated with suppression of estrogen action, implicating this GTPase in a growth-inhibitory mechanism associated with antiestrogen treatment of breast cancer. PMID: 16914723
  23. R-Ras and ILK have roles upstream of GSK-3beta in the regulation of neuronal polarity PMID: 17107957
  24. Notch1 ligand, Delta-like ligand-4, stimulates R-Ras-dependent alpha 5 beta 1 integrin-mediated adhesion, demonstrating the physiological relevance of this pathway. PMID: 17664272
  25. results map the functional elements in the R-ras promoter sequence and suggest that the GABP may be critical for transcription of R-ras and for maintenance of normal blood vessel functions through the regulation of this gene PMID: 19011236
  26. TCF8 activates R-Ras, another class of angiogenic regulator, to suppress angiogenesis by a mechanism other than a transcriptional attenuator. PMID: 19116136

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Subcellular Location Cell membrane, Lipid-anchor, Cytoplasmic side
Protein Families Small GTPase superfamily, Ras family
Database Links

HGNC: 10447

OMIM: 165090

KEGG: hsa:6237

STRING: 9606.ENSP00000246792

UniGene: Hs.515536

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