SERPINE1 Antibody, FITC conjugated

Datasheet
Code CSB-PA11239C0Rb
Size US$299
Uniprot No. P05121
Immunogen Recombinant Human Plasminogen activator inhibitor 1 protein (24-398AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:8481516, PubMed:9207454, PubMed:17912461). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084).
Form Liquid
Conjugate FITC
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Plasminogen activator inhibitor 1 (PAI) (PAI-1) (Endothelial plasminogen activator inhibitor) (Serpin E1), SERPINE1, PAI1 PLANH1
Immunogen Species Human
Protocols ELISA Protocol
Research Area Cardiovascular
Target Names SERPINE1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Serine protease inhibitor. Inhibits TMPRSS7
Involvement in disease Plasminogen activator inhibitor-1 deficiency (PAI-1D)
Subcellular Location Secreted
Protein Families Serpin family
Tissue Specificity Expressed in endothelial cells (PubMed:2430793, PubMed:3097076). Found in plasma, platelets, and hepatoma and fibrosarcoma cells.
Database Links

HGNC: 8583

OMIM: 173360

KEGG: hsa:5054

STRING: 9606.ENSP00000223095

UniGene: Hs.414795

Pathway HIF-1 signaling pathway
Hippo signaling pathway
p53 signaling pathway
Cellular senescence
Complement and coagulation cascades
AGE-RAGE signaling pathway in diabetic complications
Apelin signaling pathway

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