SH3GLB1 Antibody, HRP conjugated

Datasheet
Code CSB-PA878084LB01HU
Size US$299
Uniprot No. Q9Y371
Immunogen Recombinant Human Endophilin-B1 protein (1-365AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance May be required for normal outer mitochondrial membrane dynamics (PubMed:15452144). Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion (PubMed:11604418). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts. Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PubMed:17891140). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PubMed:21068542). Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability.
Form Liquid
Conjugate HRP
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Endophilin-B1 (Bax-interacting factor 1) (Bif-1) (SH3 domain-containing GRB2-like protein B1), SH3GLB1, KIAA0491
Immunogen Species Human
Protocols ELISA Protocol
Research Area Cell Biology
Target Names SH3GLB1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function May be required for normal outer mitochondrial membrane dynamics
Subcellular Location Cytoplasm, Golgi apparatus membrane, Peripheral membrane protein, Mitochondrion outer membrane, Peripheral membrane protein, Cytoplasmic vesicle, autophagosome membrane, Midbody
Protein Families Endophilin family
Tissue Specificity Highly expressed in heart, skeletal muscle, kidney and placenta. Detected at lower levels in brain, colon, thymus, spleen, liver, small intestine, lung and peripheral blood leukocytes.
Database Links

HGNC: 10833

OMIM: 609287

KEGG: hsa:51100

UniGene: Hs.136309

Pathway Autophagy
Endocytosis

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