SMAD6 Antibody

Datasheet
Code CSB-PA009964
Size US$167
Uniprot No. O43541
Immunogen Synthesized peptide derived from the Internal region of Human Smad6.
Raised in Rabbit
Species Reactivity Human,Mouse
Tested Applications WB,IHC,ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/40000
Form Liquid
Conjugate Non-conjugated
Storage Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Alias SMAD6; MADH6; Mothers against decapentaplegic homolog 6; MAD homolog 6; Mothers against DPP homolog 6; SMAD family member 6; SMAD 6; Smad6; hSMAD6
Immunogen Species Homo sapiens (Human)
Protocols Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
Target Names SMAD6
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.
Involvement in disease Aortic valve disease 2 (AOVD2); Craniosynostosis 7 (CRS7)
Subcellular Location Nucleus
Protein Families Dwarfin/SMAD family
Tissue Specificity Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.
Database Links

HGNC: 6772

OMIM: 602931

KEGG: hsa:4091

STRING: 9606.ENSP00000288840

UniGene: Hs.153863

Pathway TGF-beta signaling pathway

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