SOX2 Antibody, Biotin conjugated

Datasheet
Code CSB-PA16539D0Rb
Size US$299
Uniprot No. P48431
Immunogen Recombinant Human Transcription factor SOX-2 protein (1-317AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 By similarity. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal By similarity. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Transcription factor SOX-2, SOX2
Immunogen Species Human
Protocols ELISA Protocol
Research Area Neuroscience
Target Names SOX2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
Involvement in disease Microphthalmia, syndromic, 3 (MCOPS3)
Subcellular Location Nucleus
Database Links

HGNC: 11195

OMIM: 184429

KEGG: hsa:6657

STRING: 9606.ENSP00000323588

UniGene: Hs.518438

Pathway Hippo signaling pathway
Signaling pathways regulating pluripotency of stem cells

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