TBC1D15 Antibody, Biotin conjugated

Code CSB-PA823452LD01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) TBC1D15 Polyclonal antibody
Uniprot No. Q8TC07
Target Names TBC1D15
Alternative Names DKFZp686M1379 antibody; DKFZp761D0223 antibody; FLJ12085 antibody; FLJ33191 antibody; GAP for RAB7 antibody; GTPase-activating protein RAB7 antibody; RAB7 GAP antibody; Rab7-GAP antibody; TBC1 domain family member 15 antibody; TBC15_HUMAN antibody; Tbc1d15 antibody; Tre 2 budding uninhibited by benzimidazole cell division cycle 16 domain; domain family member 15 antibody; Tre2/Bub2/Cdc16 domain family member 15 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human TBC1 domain family member 15 protein (283-404AA)
Immunogen Species Homo sapiens (Human)
Conjugate Biotin
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity).
Gene References into Functions
  1. Report provides evidence for a new function of TBC1D15 in the control of GLUT4 vesicles translocation through regulating Rab7 activity. Glucose uptake was greatly reduced when TBC1D15 was knocked out. PMID: 30316925
  2. Demonstrate that TBC1D15 and TBC1D17 mediate proper autophagic encapsulation of mitochondria by regulating Rab7 activity at the interface between mitochondria and isolation membranes. PMID: 24569479
  3. TBC1D15 is required for the accumulation of RhoA. PMID: 24337944
  4. Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology. PMID: 23077178
  5. although only TBC1D15/Rab7-GAP altered Rab7-GTP levels, both Rab7-GAP and mVps39 regulate lysosomal morphology and play a role in maintaining growth factor dependence PMID: 20363736
  6. This paper primarily describes mouse TBC1D15 but also reports the primary structure of human TBC1D15. PMID: 16055087

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Subcellular Location Cytoplasm
Database Links

HGNC: 25694

OMIM: 612662

KEGG: hsa:64786

STRING: 9606.ENSP00000448182

UniGene: Hs.284630

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