TCHH Antibody, HRP conjugated

Datasheet
Code CSB-PA023309OB01HU
Size US$299
Uniprot No. Q07283
Immunogen Peptide sequence from Human Trichohyalin protein (1922-1941AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation.
Form Liquid
Conjugate HRP
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Antigen Affinity Purified
Isotype IgG
Clonality Polyclonal
Alias Trichohyalin, TCHH, THH THL TRHY
Immunogen Species Human
Protocols ELISA Protocol
Research Area Signal Transduction
Target Names TCHH
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation.
Involvement in disease Uncombable hair syndrome 3 (UHS3)
Protein Families S100-fused protein family
Tissue Specificity Found in the hard keratinizing tissues such as the inner root sheath (IRS) of hair follicles and medulla, and in the filiform papillae of dorsal tongue epithelium.
Database Links

HGNC: 11791

OMIM: 190370

KEGG: hsa:7062

STRING: 9606.ENSP00000357794

UniGene: Hs.432416

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