TLR2 Antibody

Datasheet
Code CSB-PA449240
Size US$299
Uniprot No. O60603
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA449240(TLR2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA449240(TLR2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
  • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Raw264.7, A549 cells, Primary antibody: CSB-PA449240(TLR2 Antibody) at dilution 1/525, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
Immunogen Fusion protein of Human TLR2
Raised in Rabbit
Species Reactivity Human,Mouse
Tested Applications ELISA,WB,IHC;ELISA:1:1000-1:5000,WB:1:200-1:1000,IHC:1:50-1:200
Relevance The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias toll-like receptor 2
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Target Names TLR2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides
Subcellular Location Membrane, Single-pass type I membrane protein, Cytoplasmic vesicle, phagosome membrane, Single-pass type I membrane protein, Membrane raft
Protein Families Toll-like receptor family
Tissue Specificity Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.
Database Links

HGNC: 11848

OMIM: 246300

KEGG: hsa:7097

STRING: 9606.ENSP00000260010

UniGene: Hs.519033

Pathway PI3K-Akt signaling pathway
Toll-like receptor signaling pathway

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