TNFRSF13C Antibody, HRP conjugated

Code CSB-PA853495LB01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) TNFRSF13C Polyclonal antibody
Uniprot No. Q96RJ3
Target Names TNFRSF13C
Alternative Names B cell activating factor receptor antibody; B-cell-activating factor receptor antibody; BAFF R antibody; BAFF receptor antibody; BAFF-R antibody; BAFFR antibody; BLyS receptor 3 antibody; BlySR3 antibody; BR 3 antibody; BR3 antibody; BROMIX antibody; CD 268 antibody; CD268 antibody; CD268 antigen antibody; CVID4 antibody; MGC138235 antibody; OTTHUMP00000028746 antibody; Prolixin antibody; TNFRSF 13C antibody; Tnfrsf13c antibody; TR13C_HUMAN antibody; Tumor necrosis factor receptor subunit member 13C antibody; Tumor necrosis factor receptor superfamily member 13C antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Tumor necrosis factor receptor superfamily member 13C protein (1-78AA)
Immunogen Species Homo sapiens (Human)
Conjugate HRP
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.
Gene References into Functions
  1. the B-cell receptor BR3 modulates cellular branching via Rac1 during neuronal migration PMID: 27436754
  2. Expression patterns of BAFF and its receptor BAFF-R differ according to lupus nephritis class. PMID: 29087261
  3. up-regulated expression in intractable temporal lobe epilepsy PMID: 28441631
  4. Inhibition of ADAM10 augments BAFF-dependent survival of primary human B cells, whereas inhibition of ADAM17 increases BAFFR expression levels. PMID: 28249164
  5. Relationships between serum BAFF and BBR expression [(BAFFR, calcium signal modulating cyclophilic ligand interactor (TACI) and B cell maturation antigen (BCMA)] were determined on B cell subsets, defined using immunoglobulin (Ig)D/CD38. Twenty pre-RTX and 18 rheumatoid arthritis patients relapsing after B cell depletion were included. PMID: 28800164
  6. Among the BAFF receptors in a cohort of rheumatoid arthritis (RA) patients, the AA have shown, by fluorescence activated cell sorter (FACS) analysis of median fluorescence intensity (MFI), that transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) and B cell maturation antigen (BCMA) do not change PMID: 28834574
  7. The expression levels of serum BAFF and the three receptors (TACI, BCMA and BAFF-R) in non-Hodgkin lymphoma patients were significantly higher than in healthy controls. PMID: 28028945
  8. Variants in BAFF-R gene is associated with chronic lymphocytic leukemia. PMID: 27468724
  9. BAFF-R, as the principal receptor of BAFF, not only decreased the apoptosis of B cells and CD8+ T cells by upregulating the expression of Bcl-2 and BclxL, but also promoted B-cell proliferation in immune thrombocytopenia. PMID: 26749059
  10. genetic polymorphism contributes to the pathogenesis of primary antibody deficiency PMID: 26613719
  11. BAFF and BAFF-R are expressed in the thyrocytes derived from patients with either autoimmune thyroid disorders or multinodular goiter, as well in the infiltrating immune cells of Graves' disease and Hashimoto's thyroiditis PMID: 26214745
  12. There is an increased prevalence of the BAFF-R His159Tyr mutation in patients with Sjogren's syndrome (SS), particularly in those with SS complicated by MALT lymphoma whose disease onset occurred at a younger age. PMID: 26097183
  13. Expression of mutant caspase-9 correlated with a downregulation of BAFFR (B-cell-activating factor belonging to the TNF family (BAFF) receptor) in B cells and ICOS (inducible T-cell costimulator) in T cells. PMID: 25569260
  14. Variants of TNFRSF13C were associated with common variable immunodeficiency. PMID: 26122175
  15. Negative expression of BAFF-R, but not of BAFF, could be an independent risk factor for progression-free survival and Overall survival in patients with diffuse large B-cell lymphoma treated with standard R-CHOP. PMID: 26327569
  16. the common TLR4-D299G, TLR4-T399I and BAFFR-P21R polymorphisms provide the carriers with a protective advantage against ICU-acquired sepsis; this finding was more profound for medical patients compared to trauma or surgical ones PMID: 25454804
  17. Data show significant differences in expression of tumour necrosis factor family (BAFF) receptors BAFF-R, BCMA and TACI in patients with and without anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies. PMID: 25301447
  18. In view of the restricted expression of the BAFF-R on normal cells and the multiple anti-pre-B ALL activities stimulated by this antibody, a further examination of its use for treatment of pre-B ALL is warranted. PMID: 24825858
  19. Availability of BAFF determines BAFF-R and TACI expression on B cells in common variable immunodeficiency. PMID: 24809296
  20. Our study demonstrates that BR3 is involved in the survival of cultured epithelial cells due to an autocrine effect of BAFF. PMID: 24602383
  21. BAFF-R, but not BAFF, may have a role in progression-free survival and overall survival in follicular lymphoma PMID: 23272079
  22. BLyS and its receptors are expressed by B lymphocytes in the peripheral blood and the bone marrow of patients with multiple myeloma. PMID: 23276925
  23. P21R/H159Y TNFRSF13C compound heterozygous mutation and P21R heterozygous mutations were detected in Turkish patients with common variable immunodeficiency. PMID: 22699762
  24. BAFF-R expression is tightly regulated during B-cell development in mouse and human and this exprssion is correlated with posirive selection. PMID: 22028296
  25. It was also found that NF-kappaB was an important transcription factor involved in regulating BAFF-R expression through one NF-kappaB binding site in the BAFF-R promoter PMID: 21607696
  26. Soluble BAFF levels inversely correlate with peripheral B cell numbers and the expression of BAFF receptors. PMID: 22124120
  27. The activation profile of diffuse large B-cell lymphomas/posttransplantation lymphoproliferative disorders was not associated with BAFF/BAFF-R expression, whereas nuclear p52 activation might be linked to Epstein-Barr virus. PMID: 21871426
  28. The human BAFF-R gene might be regulated via a transcriptional event through one putative NF-kappaB site on the BAFF-R gene promoter. PMID: 21744373
  29. reduced expression via inhibition of the NF-KappaB pathway in B cells of rheumatoid arthritis patients PMID: 21515993
  30. primary leukemia B-cell precursors aberrantly express receptors of the BAFF-system, BAFF-R, BCMA, and TACI PMID: 21687682
  31. This is the first study, presenting together the TNFSF members APRIL, BAFF, TWEAK and their receptors in different areas of normal renal tissue and renal cell carcinoma. PMID: 21483105
  32. BLyS and its receptors might have a potential role in the growth and survival of malignant plasma cells. PMID: 19731825
  33. Results describe the mechanisms underlying aberrant BAFF-R expression in precursor B acute lymphoblastic leukemia (precursor B-ALL) and mature B chronic lymphocytic leukemia (CLL). PMID: 21099364
  34. BAFF-R was rather specifically related to low growth activity of germinal center B-cell-like -type diffuse large B-cell lymphoma of nodal origin. PMID: 21123970
  35. inverse correlation between BAFF and APRIL in Kawasaki disease is reversed by IVIG treatment PMID: 20945608
  36. Elevated plasma BAFF and reduced BAFF receptor 3 (BR3) protein expression on peripheral B cells could act as biomarkers for active disease in systemic lupus erythematosus patients PMID: 20974656
  37. a novel lymphoma-associated mutation in human BAFF-R that results in NF-kappaB activation and reveals TRAF6 as a necessary component of normal BAFF-R signaling. PMID: 21041452
  38. Data from BAFF-R-expressing cells suggested potential regulatory sites in TNFRSF13C promoter region. PMID: 20554963
  39. This report is the first showing universal expression of BAFF-R by pre-B ALL cells. PMID: 20460528
  40. IFN-gamma and the NF-kappaB pathway could be involved in regulating the transcription and mRNA expression of BAFF-R gene. PMID: 20230666
  41. the mechanism of transcriptional regulation of BAFF-R PMID: 20025535
  42. BAFF-R is a receptor for the TNF family member ligand, BAFF [review] PMID: 12456020
  43. BAFFR-mediated NF-kappa B activation and IL-10 production in B cells is downregulated by TNFR-associated factor-3. PMID: 12471121
  44. crystal structure and interaction with BAFF protein PMID: 12715002
  45. BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site. PMID: 12755599
  46. Expression of BCMA, TACI, and BAFF-R by multiple myeloma cells support cell growth and survival. PMID: 14512299
  47. This study reports the crystal structure of a 24-residue fragment of the cytoplasmic portion of BAFF-R bound in complex with TRAF3. PMID: 15585864
  48. the PVPAT sequence of BAFFR not only functions as a key signaling motif of BAFFR but also determines its signaling specificity in the induction of the noncanonical NF-kappaB pathway PMID: 15644327
  49. amino acid sequence of genomic DNA from blood of common variable immunodeficiency patients;mutations may result in humoral immunodeficiency PMID: 16160919
  50. BAFF-R is expressed on most mature B cells and B-cell lymphoproliferative disorders. PMID: 16226112
  51. BAFF-R is consistently occupied on blood B cells in systemic lupus erythematosus PMID: 16320342
  52. Detection in lymphoma tissue biopsies may be of clinical relevance in predicting response to treatment. PMID: 16769579
  53. BR3, which is expressed on all mature B cells, is a specific receptor for the B-cell survival and maturation factor BAFF. PMID: 16840730
  54. Review. The splice variants, binding specificities, structural determinants for ligand selectivity, and signaling pathways are reviewed. PMID: 16914324
  55. Review. BLyS signaling via BR3 is the dominant homeostatic regulator of primary B cell pools. PMID: 16919470
  56. Review. BAFF and its receptor have roles in B cell biology outside of a survival mechanism. These include germinal center maintenance, isotype switching, and regulation of specific B cell surface markers. PMID: 16931038
  57. Review. Direct BAFF/APRIL signalling in T cells and/or T cell modulation in response to a BAFF-modified B cell compartment may play an important role in inflammation and immunomodulation. PMID: 16931039
  58. recombinant gelonin/B lymphocyte stimulator fusion toxin may have potential therapeutic efficacy for B-CLL patients PMID: 17119117
  59. BAFF-R and CD40 enhance B cell responsiveness to transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI)-mediated suppression. PMID: 17154264
  60. Widely expressed in the synovial tissue of patients with rheumatoid arthritis. PMID: 17963166
  61. The BAFF-binding receptor profile may serve as a footprint of the activation history and stage of differentiation of normal human B cells. PMID: 18025170
  62. Of 9 CVID patients...No mutations of SAP, ICOS, TACI, BAFFR, and CD19 were identified PMID: 18051214
  63. We propose that an aberrant BAFF/BAFF-R-dependent autocrine mechanism may play a role in the development of certain types of nonhematopoietic cancer cells. PMID: 18775026
  64. the assessment of expression of BAFF-binding receptors aids subclassification and prognostication of DLBCL PMID: 19207947
  65. deletion of the BAFF-R gene in humans causes a characteristic immunological phenotype but it does not necessarily lead to a clinically manifest immunodeficiency PMID: 19666484
  66. molecular mechanisms underlying this crosstalk between B cell receptor and BAFF receptor signaling that maintain B cell survival and metabolic fitness PMID: 19726767

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Involvement in disease Immunodeficiency, common variable, 4 (CVID4)
Subcellular Location Membrane, Single-pass type III membrane protein
Tissue Specificity Highly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes.
Database Links

HGNC: 17755

OMIM: 606269

KEGG: hsa:115650

STRING: 9606.ENSP00000291232

UniGene: Hs.344088

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