Recombinant Bovine Insulin-like growth factor-binding protein 2(IGFBP2)

Code CSB-YP011096BO
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Source Yeast
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Code CSB-EP011096BO
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Source E.coli
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Code CSB-EP011096BO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP011096BO
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Source Baculovirus
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Code CSB-MP011096BO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names IGFBP2
Uniprot No. P13384
Alternative Names IGFBP2Insulin-like growth factor-binding protein 2; IBP-2; IGF-binding protein 2; IGFBP-2
Species Bos taurus (Bovine)
Expression Region 34-317
Target Protein Sequence EVLFRCP PCTPESLAAC KPPPGAAAGP AGDARVPCEL VREPGCGCCS VCARLEGERC GVYTPRCGQG LRCYPNPGSE LPLRALVHGE GTCEKHGDAE YSASPEQVAD NGEEHSEGGL VENHVDGNVN LMGGGGGAGR KPLKSGMKEL AVFREKVTEQ HRQMGKGGKH HLGLEEPKKL RPPPARTPCQ QELDQVLERI STMRLPDERG PLEHLYSLHI PNCDKHGLYN LKQCKMSLNG QRGECWCVNP NTGKLIQGAP TIRGDPECHL FYNEQQGARG VHTQRMQ
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Gene References into Functions
  1. Five novel SNPs were identified in IGFBP2, two of which had significant associations with fertility (age at conception in heifers and commencement of luteal activity) and 305-day milk yield in lactation 1. PMID: 22537059
  2. The present study suggests that the insulin like growth factor (IGF) system or imbalances between IGF and IGF binding proteins may be involved in cystic ovary disease of cattle. PMID: 21940120
  3. in preovulatory follicles, PAPP-A is responsible for IGF-dependent IGFBP-2 degradation PMID: 12493698
  4. spatial and temporal patterns of expression of IGFBP-2 and -3 were markedly altered in the placentomes of nuclear transfer pregnancies PMID: 14561651
Subcellular Location Secreted.
Database Links

KEGG: bta:282260

UniGene: Bt.149

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Address
7505 Fannin St. Ste 610-312, Houston, TX 77054, USA
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