Recombinant Bovine Lysine-specific demethylase 8(JMJD5)

Product Type Recombinant Protein
Uniprot No. Q1JP61
Abbreviation JMJD5
Species Bos taurus (Bovine)
Gene Names KDM8
Protein Names Recommended name: Lysine-specific demethylase 8 EC= 1.14.11.27 Alternative name(s): JmjC domain-containing protein 5 Jumonji domain-containing protein 5
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Function Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation. In a complex with coregulator RCCD1, is also able to demethylate trimethylated 'Lys-36' (H3K36me3) of histone H3. Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with RCCD1. Possibly together with RCCD1, involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha-tubulin acetylation and cytoskeletal microtubule stability (By similarity). Might function as a protein hydroxylase (Potential). Under stress conditions that cause a DNA damage response, acts as a histone protease by cleaving the N-terminal tail of histone H3 at the carboxyl side of monomethyl-lysine (Kme1) residues, preferably at monomethylated 'Lys-9' (H3K9me1). The histone variant H3F3A is the major target for cleavage.
Subcellular Location Nucleus, Chromosome
Database Links

KEGG: bta:507905

STRING: 9913.ENSBTAP00000026023

UniGene: Bt.45836

Product Details for Different Expression Systems

Product Name Recombinant Bovine Lysine-specific demethylase 8(JMJD5),Yeast
Code CSB-YP629263BO
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MAGPSTLWET LQALLPHTKE ELKLELGEKV EGSVLMLLQE AAELFLGGQR RECLQTCEVL LDYSWEKLNT GPWQHVDKDW RRVYAFGCLL KAVCLCEPPG DAASVAAALK ACDMGLLMGA AILGDILLKV AAVLQKYLLS GKRPAPGPSQ EPPGTKKARN DHVPIPDVTT ERTVPRLHCP SLQYFKKHFL VPGRPVILEG VANHWPCMKK WSLEYIQEVA GCRTVPVEVG SRYTDEEWSQ TLMTVNEFIS KYIREEPKDI GYLAQHQLFD QIPELKQDIS IPDYCCLGDG EEEEITINAW FGPQGTVSPL HQDPQQNFLA QVMGRKYIRL YSPQESEALY PHDTHLLHNT SQVDVENPDL EKFPRFAEAP FLSCVLSPGE VLFIPVKHWH YVRALDLSFS VSFWWS
Expression Region 1-406
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
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Product Name Recombinant Bovine Lysine-specific demethylase 8(JMJD5),E.coli
Code CSB-EP629263BO
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MAGPSTLWET LQALLPHTKE ELKLELGEKV EGSVLMLLQE AAELFLGGQR RECLQTCEVL LDYSWEKLNT GPWQHVDKDW RRVYAFGCLL KAVCLCEPPG DAASVAAALK ACDMGLLMGA AILGDILLKV AAVLQKYLLS GKRPAPGPSQ EPPGTKKARN DHVPIPDVTT ERTVPRLHCP SLQYFKKHFL VPGRPVILEG VANHWPCMKK WSLEYIQEVA GCRTVPVEVG SRYTDEEWSQ TLMTVNEFIS KYIREEPKDI GYLAQHQLFD QIPELKQDIS IPDYCCLGDG EEEEITINAW FGPQGTVSPL HQDPQQNFLA QVMGRKYIRL YSPQESEALY PHDTHLLHNT SQVDVENPDL EKFPRFAEAP FLSCVLSPGE VLFIPVKHWH YVRALDLSFS VSFWWS
Expression Region 1-406
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Bovine Lysine-specific demethylase 8(JMJD5),Baculovirus
Code CSB-BP629263BO
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MAGPSTLWET LQALLPHTKE ELKLELGEKV EGSVLMLLQE AAELFLGGQR RECLQTCEVL LDYSWEKLNT GPWQHVDKDW RRVYAFGCLL KAVCLCEPPG DAASVAAALK ACDMGLLMGA AILGDILLKV AAVLQKYLLS GKRPAPGPSQ EPPGTKKARN DHVPIPDVTT ERTVPRLHCP SLQYFKKHFL VPGRPVILEG VANHWPCMKK WSLEYIQEVA GCRTVPVEVG SRYTDEEWSQ TLMTVNEFIS KYIREEPKDI GYLAQHQLFD QIPELKQDIS IPDYCCLGDG EEEEITINAW FGPQGTVSPL HQDPQQNFLA QVMGRKYIRL YSPQESEALY PHDTHLLHNT SQVDVENPDL EKFPRFAEAP FLSCVLSPGE VLFIPVKHWH YVRALDLSFS VSFWWS
Expression Region 1-406
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Bovine Lysine-specific demethylase 8(JMJD5),Mammalian cell
Code CSB-MP629263BO
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MAGPSTLWET LQALLPHTKE ELKLELGEKV EGSVLMLLQE AAELFLGGQR RECLQTCEVL LDYSWEKLNT GPWQHVDKDW RRVYAFGCLL KAVCLCEPPG DAASVAAALK ACDMGLLMGA AILGDILLKV AAVLQKYLLS GKRPAPGPSQ EPPGTKKARN DHVPIPDVTT ERTVPRLHCP SLQYFKKHFL VPGRPVILEG VANHWPCMKK WSLEYIQEVA GCRTVPVEVG SRYTDEEWSQ TLMTVNEFIS KYIREEPKDI GYLAQHQLFD QIPELKQDIS IPDYCCLGDG EEEEITINAW FGPQGTVSPL HQDPQQNFLA QVMGRKYIRL YSPQESEALY PHDTHLLHNT SQVDVENPDL EKFPRFAEAP FLSCVLSPGE VLFIPVKHWH YVRALDLSFS VSFWWS
Expression Region 1-406
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

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