||Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion. Acts as a cell-cell contact-dependent endothelial calcium entry channel (By similarity).
||Membrane, Multi-pass membrane protein, Cell membrane, Multi-pass membrane protein
||Transient receptor (TC 1.A.4) family, STrpC subfamily, TRPC4 sub-subfamily
||Expressed in adrenal gland. Lower expression in heart and retina. Also expressed in testis. The short isoform is specifically expressed in the adrenal gland.