Recombinant Bovine Toll-like receptor 2 (TLR2), partial

1. results suggest that polymorphisms in the TLR2 gene might not play a significant role in the BTB risk in Chinese Holstein cattle PMID: 28413050
2. Transcription levels of TLR2, TLR4, and CD14 in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum. PMID: 26777563
3. We structurally defined with 5'-RACE experiments three promoters (P1-3) controlling TLR2 expression in udder, liver and other tissues of cows suffering from E. coli mastitis. PMID: 26235600
4. TLR2 and TLR4 mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells. PMID: 26048276
5. positive correlation between lower neutrophil apoptosis and higher expression of TLR2 and TLR4 with the formation of NETs and change in surface architecture. PMID: 24915786
6. TLR2, TLR1, and TLR6 haev roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides by epithelial and stromal cells of bovine endometrium PMID: 24437488
7. Data suggest that granulosa cells from dominant follicles express functional TLR2 and TLR4; granulosa cells appear to participate in innate immunity by responding to bacterial lipopolysaccharides/lipopeptides via TLR2 and TLR4 signaling pathways. PMID: 23825132
8. The expressions of host TLR2 and 4 genes were significantly higher in acidosis-resistant steers compared to those in acidosis-susceptible steers. PMID: 22622335
9. Whereas previous results regarding the TLR1 gene were not corroborated, a risk haplotype was detected in TLR2; however, its low frequency indicates that this detected association should be interpreted with caution. PMID: 21700053
10. The identification of antibodies specific for bovine and ovine TLR2 will facilitate studies of the role of this important pattern recognition receptors in the initiation of immune responses to important pathogens. PMID: 21067818
11. ALOX5AP, CPNE3, IL1R2, IL6, TLR2, TLR4, and THY1 were upregulated in blood polymorphonuclear cells in negative energy balance versus positive energy balance cows. PMID: 20072847
12. This study showed that TLR1 and TLR2 together are necessary for the recognition of triacylated lipopeptides. PMID: 20167196
13. The functional studies suggest that genetic polymorphisms in bovine TLR2 which result in higher macrophage activity may contribute to enhanced T cell activation and a lower susceptibility to paratuberculosis in cattle. PMID: 20005587
14. fine mapping of bovine toll-like receptor 4 and toll-like receptor 2 regions PMID: 12584610
15. mRNA abundances of TLR9, TLR2, and TLR4 together with those of beta-defensin 5 (BNBD5), an early bactericidal effector molecule of the innate system, in healthy and infected mammary glands PMID: 14715566
16. Microcrystals of calcium pyrophosphate dihydrate and monosodium urate use TLR2-mediated signaling in chondrocytes to trigger NO generation. PMID: 15814732
17. both S. aureus and E. coli pathogens activate equally well bovine TLR2 and TLR4 receptors to induce NF-kappaB activation PMID: 17936907
18. This study indicates that SNP c.3020A>T might play a role in the host response against mastitis and further detailed studies are needed to understand its functional mechanisms. PMID: 18005441
19. A combined linkage and linkage disequilibrium method was used to investigate possible associations between the TLR2 and THR4 genes and mastitis susceptibility recorded in the Norwegian Red cattle population. PMID: 18363976
20. Analysis of sequence variability and protein domain architectures for bovine peptidoglycan recognition protein 1 and Toll-like receptors 2 and 6. PMID: 18639626
21. Three missense mutations at T385 G, G398A, and G1884A were detected in the coding region that encoded extracellular domain. PMID: 19544205

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KEGG: bta:281534

STRING: 9913.ENSBTAP00000010530

UniGene: Bt.8945