||In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation (By similarity). Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate, which are then moved relative to actin filaments. Stimulates the formation and elongation of filopodia. Regulates cell shape, cell spreading and cell adhesion. Plays a role in formation of the podosome belt in osteoclasts.
||Cytoplasm, cytosol, Cell projection, lamellipodium, Cell projection, ruffle, Cytoplasm, cytoskeleton, Cell projection, filopodium tip, Cytoplasm, cell cortex, Cell projection, filopodium membrane, Peripheral membrane protein
||TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
||Detected in kidney, testis, liver, kidney, cerebellum and brain cortex (at protein level).
Fc gamma R-mediated phagocytosis