Recombinant Bovine Vascular endothelial growth factor A (VEGFA)

1. data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes. PMID: 27872190
2. Studied the effect of cyclic uniaxial stretch (20%, 1 Hz), with and without the stimulation of vascular endothelial growth factor (VEGF), on sprouting angiogenesis by employing a stretchable three-dimensional cell culture model. PMID: 25376776
3. Study shows that VEGFA mRNA in mammalian endothelial cells undergoes programmed translational readthrough (PTR) generating VEGF-Ax, an isoform containing a unique 22-amino-acid C terminus extension. PMID: 24949972
4. Data indicate that superoxide dismutase (SOD) inhibited high glucose (HG)-induced expression of uPAR and VEGF in bovine retinal microvascular endothelial cell (REC). PMID: 23951261
5. Exposure of endothelial cells to VEGF, high glucose, or hydrogen peroxide up-regulated the XBP1/IRE1 alpha and ATF6 arms of the unfolded protein response compared with untreated cells. PMID: 23395094
6. Microvascular endothelial cells are more susceptible than aortic cells to advanced glycation end products-enhanced permeability and that AGE-enhanced permeability is dependent on VEGF expression induced by reactive oxygen species. PMID: 21296593
7. VEGF supports germ cell survival and sperm production in bulls. PMID: 19633133
8. analysis of polymorphisms of bovine VEGF gene and their associations with growth traits in Chinese cattle PMID: 20376703
9. VEGF mRNA expression at estrus was higher than at the early I, early II and late luteal stages (P<0.05), whereas VEGF protein content was greatest at the early I luteal stage and decreased thereafter PMID: 20035107
10. Alterations in the expression of VEGF-A and bFGF systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates. PMID: 20198587
11. Advanced glycation end products increase, through a protein kinase C-dependent pathway, expression in reignal endothelial cells; inhibited by gliclazide. PMID: 12126787
12. VEGF signaling is regulated by atrial natriuretic peptide, which preserves endothelial cell tight junction functional morphology PMID: 12213803
13. Airline pilots are good candidates to see if mutation in the VEGF promoter are responsible for some cases of amyotrophic lateral sclerosis. PMID: 12448348
14. role in dowregulating Flk-1/KDR involves Cbl-mediated ubiquitination PMID: 12649282
15. interaction with glucose-6-phosphate dehydrogenase is involved in angiogenesis PMID: 12777375
16. Results suggest that leptin might elicit angiogenesis through vascular endothelial growth factor induction as well as pigment epithelium-derived factor suppression in pericytes. PMID: 12779248
17. Shear stress and VEGF converge at the membrane receptor Flk-1 and these stimuli share the Flk-1/Cbl/Akt pathway in activating IKK activation. PMID: 14551058
18. Tumor cells activate confluent, quiescent EC, promoting survival, phenotypic, and gene expression changes. Of importance, VEGF antagonism converts tumor-conditioned medium from protective to endothelial cell-damaging effects. PMID: 15075216
19. MGP plays a role in endothelial cell function, by increasing transforming growth factor-beta1 activity and stimulating VEGF expression PMID: 15456771
20. placenta growth factor expression is regulated by both VEGF and hyperglycaemia via VEGFR-2 PMID: 15501243
21. VEGF has a role in increasing paracellular transport PMID: 15501249
22. Thrombospondin-1 and -2 were coordinately expressed in the extravascular compartment of the ovary during early follicle development. VEGF was inversely expressed, with expression increasing as follicles developed. PMID: 15616224
23. the activation of VEGFR-1 and VEGFR-2 heterodimer (VEGFR-1/R-2) is essential for PGI(2) synthesis mediated by VEGF-A(165) and VEGF-A(121), which cannot be reproduced by the parallel activation of VEGFR-1 and VEGFR-2 homodimers with corresponding agonists PMID: 15637071
24. Reciprocally, adenovirus-mediated overexpression of Cyr61 in cells cultured under static conditions increased the expression of VEGF, alpha(v)-integrin, and SM alpha-actin. PMID: 15649872
25. peroxynitrite causes increased expression of VEGF in vascular endothelial cells by a process that requires the activation of STAT3 PMID: 16257644
26. ROS induce expression not only of VEGF but also of VEGFR2. VEGFR2 increase by ROS is mainly driven through a NF-kappaB-dependent pathway. PMID: 16899768
27. expression of VEGF isoforms may be associated with characterization of the preovulatory phenotype during follicle development in the bovine ovary PMID: 17043385
28. Gab1 is a novel critical regulatory component of endothelial cell migration and capillary formation with a key role in the activation of VEGF-evoked signaling pathways required for angiogenesis PMID: 17178724
29. The results provide support for a role for VEGF in the primary to secondary follicle transition. PMID: 17290425
30. This study reports the temporal changes in vascular endothelial growth factor A (VEGFA), fibroblast growth factor 2 (FGF2) and osteonectin during the follicular-luteal transition and corpus luteum development in the cow. PMID: 17360962
31. a new molecular cascade, operating in retinal bovine pericytes and involving PKCbetaII, the mRNA-stabilizing protein HuR. and VEGF. In particular we show that PKCbetaII activation is responsible, through the RNA-binding protein HuR PMID: 18206386
32. bFGF and VEGF control the corpus luteum formation and function. PMID: 18213648
33. VEGF has an effect on the expression of its own transcription factor, HIF-1, and on VEGF itself PMID: 18305118
34. By regulating VEGFR2 expression and activation, PKC-epsilon expression is critical for activation of Akt and eNOS by VEGF and contributes to VEGF-stimulated Erk activation, whereas PKC-alpha has opposite effects. PMID: 18323518
35. Angiopoietin-2 may support the angiogenic effects of VEGF-A in these corpus luteum stages. PMID: 18541291
36. DNA methylation of VEGF in blg(+/-) was noticeably decreased. PMID: 18789616
37. VEGF-dependent production of NO by eNOS is mediated by as cascade involving ezrin, calpain, PI-3-kinase, AMPK and AKT. PMID: 19038867
38. ALK1 and ALK5 are both essential for correct regulation of VEGF, and that disruption of either pathway leads to disease. PMID: 19506300
39. inhibition of NO production by Ang-1, via phosphorylation of eNOS on Thr(497) by PKC zeta, is responsible, at least in part, for inhibition of VEGF-stimulated endothelial permeability by Ang-1. PMID: 19564638

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KEGG: bta:281572

STRING: 9913.ENSBTAP00000056005

UniGene: Bt.4138