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Recombinant Chicken Basic helix-loop-helix transcription factor scleraxis (SCX)

Recombinant Chicken Basic helix-loop-helix transcription factor scleraxis (SCX)

Code	CSB-YP020869CH
MSDS	MSDS
Size	Pls inquire
Source	Yeast
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Code	CSB-EP020869CH
MSDS	MSDS
Size	Pls inquire
Source	E.coli
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Code	CSB-EP020869CH-B
MSDS	MSDS
Size	Pls inquire
Source	E.coli
Conjugate	Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code	CSB-BP020869CH
MSDS	MSDS
Size	Pls inquire
Source	Baculovirus
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Code	CSB-MP020869CH
MSDS	MSDS
Size	Pls inquire
Source	Mammalian cell
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

SCX

Uniprot No.

P59101

Alternative Names

SCX; Basic helix-loop-helix transcription factor scleraxis

Species

Gallus gallus (Chicken)

Expression Region

1-187

Target Protein Sequence

MSFAMLRPAA GRYLYPEISM LSEDEENGSE SSGSDEKPFH LDADGFGIKA GKRRSGKKAG RLHREPRQRH TANARERDRT NSVNTAFTAL RTLIPTEPAD RKLSKIETLR LASSYISHLG NVLLVGEACG DGQPCHTSPA FFHHGGGGGS PPPRDSENSQ PKQICTFCLS NQRKLSKDRD RKTAIRS

Protein Length

full length protein

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function

Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages.

Gene References into Functions

Gain-of-function and loss-of-function experiments in the micromass culture assay revealed a positive transcriptional influence of Fhl2 in the expression of Scleraxis. PMID: 29330921
Overexpression of Btg1 induced intense upregulation of Scleraxis. In complementary knockdown experiments, this marker was regulated in an opposite fashion. PMID: 26662056
These studies identify an important role for Scx in regulating proteoglycans in embryonic and mature valve cells. PMID: 24157418
TGF B treatments upregulate Scleraxis preceding both fibrogenesis in the micromass cultures and cartilage differentiation during interdigital ectopic chondrogenesis. PMID: 19717568
The stage dependent transcriptional regulation of Scleraxis by BMPs is a finding relevant to understand BMP's function in connective tissue differentiation. PMID: 24038612
More mature neurogenic progenitor cells express Sox2 and the bHLH transcription factor, E2A, and not Delta1 PMID: 19842182
Transcriptional activation by Pea3 and Erm in response to FGF signaling is both necessary and sufficient for Scx expression. PMID: 15253939
increased or decreased levels of phosphorylated ERK result in the loss of scleraxis transcripts, distal rib development PMID: 15716340
These findings suggest that TeM is a late marker of tendon formation and that Scx positively regulates TeM expression in a tendon cell lineage-dependent manner. PMID: 16876153