Recombinant Chicken Guanylyl cyclase-activating protein 1(GUCA1A)

Product Type Recombinant Protein
Uniprot No. P79880
Species Gallus gallus (Chicken)
Gene Names GUCA1A
Protein Names Recommended name: Guanylyl cyclase-activating protein 1 Short name= GCAP 1 Alternative name(s): Guanylate cyclase activator 1A
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Target Details This gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. This protein, guanylyl cyclase activating protein 1 (GCAP1), mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3); a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations; causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia.
Function Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure.
Tissue Specificity Retina, in rod and cone outer segments, and pineal gland.
Database Links

KEGG: gga:374216

STRING: 9031.ENSGALP00000002177

UniGene: Gga.625

Product Details for Different Expression Systems

Product Name Recombinant Chicken Guanylyl cyclase-activating protein 1(GUCA1A),Yeast
Code CSB-YP010044CH
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence GNMDGKAVE ELSATECHQW YKKFMTECPS GQLTLYEFKQ FFGLKNLSPS ANKYVEQMFE TFDFNKDGYI DFMEYVAALS LVLKGKVDQK LRWYFKLYDV DGNGCIDRGE LLNIIKAIRA INRCNEAMTA EEFTNMVFDK IDINGDGELS LEEFMEGVQK DEVLLDILTR SLDLTHIVKL IQNDGKNPHA PEEAEEAAQ
Expression Region 2-199
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Chicken Guanylyl cyclase-activating protein 1(GUCA1A),E.coli
Code CSB-EP010044CH
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence GNMDGKAVE ELSATECHQW YKKFMTECPS GQLTLYEFKQ FFGLKNLSPS ANKYVEQMFE TFDFNKDGYI DFMEYVAALS LVLKGKVDQK LRWYFKLYDV DGNGCIDRGE LLNIIKAIRA INRCNEAMTA EEFTNMVFDK IDINGDGELS LEEFMEGVQK DEVLLDILTR SLDLTHIVKL IQNDGKNPHA PEEAEEAAQ
Expression Region 2-199
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Chicken Guanylyl cyclase-activating protein 1(GUCA1A),Baculovirus
Code CSB-BP010044CH
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence GNMDGKAVE ELSATECHQW YKKFMTECPS GQLTLYEFKQ FFGLKNLSPS ANKYVEQMFE TFDFNKDGYI DFMEYVAALS LVLKGKVDQK LRWYFKLYDV DGNGCIDRGE LLNIIKAIRA INRCNEAMTA EEFTNMVFDK IDINGDGELS LEEFMEGVQK DEVLLDILTR SLDLTHIVKL IQNDGKNPHA PEEAEEAAQ
Expression Region 2-199
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Chicken Guanylyl cyclase-activating protein 1(GUCA1A),Mammalian cell
Code CSB-MP010044CH
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence GNMDGKAVE ELSATECHQW YKKFMTECPS GQLTLYEFKQ FFGLKNLSPS ANKYVEQMFE TFDFNKDGYI DFMEYVAALS LVLKGKVDQK LRWYFKLYDV DGNGCIDRGE LLNIIKAIRA INRCNEAMTA EEFTNMVFDK IDINGDGELS LEEFMEGVQK DEVLLDILTR SLDLTHIVKL IQNDGKNPHA PEEAEEAAQ
Expression Region 2-199
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

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