||Gallus gallus (Chicken)
Short name= cHIRA
TUP1-like enhancer of split protein 1
||Store at -20°C, for extended storage, conserve at -20°C or -80°C.
||Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
||This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.