Recombinant Danio rerio Growth/differentiation factor 8 (mstnb)

Code CSB-YP015057DIL
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Source Yeast
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Code CSB-EP015057DIL
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Source E.coli
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Code CSB-EP015057DIL-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP015057DIL
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Source Baculovirus
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Code CSB-MP015057DIL
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
mstnb
Uniprot No.
Alternative Names
mstnb; gdf8; mstn; mstn-1; si:ch211-3o3.2Growth/differentiation factor 8; GDF-8; Myostatin; Myostatin-1; zfMSTN-1; Myostatin-B
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
Expression Region
266-374
Target Protein Sequence
DSGLD CDENSSESRC CRYPLTVDFE DFGWDWIIAP KRYKANYCSG ECDYMYLQKY PHTHLVNKAS PRGTAGPCCT PTKMSPINML YFNGKEQIIY GKIPSMVVDR CGCS
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Acts specifically as a negative regulator of skeletal muscle growth. May down-regulate muscle-specific transcription factors such as myod and myog.
Gene References into Functions
  1. Mstnb and Inhbaa inversely control Smad2 and Smad3 transcription factor activities through alternate Activin type 2 receptors. PMID: 29196619
  2. improving muscle growth in a fish species by mixing a classical strategy, such as compensatory growth, and a biotechnological approach, such as the use of recombinant proteins for inhibiting the biological actions of MSTN(Myostatin) PMID: 24184273
  3. Fasting effect on myostatin-1 and -2 mRNA expression is strain specific. PMID: 23047051
  4. the expression of myostatin during development and the effects of its knock-down on various genes such as muscle regulatory transcription factors (MRFs), muscle-specific proteins (MSP), and insulin-like growth factors (IGFs). PMID: 15042708
  5. The results show that mstn-1 gene expression is more sensitive to nutrient conditions of fish than traditional indicators such as the RNA/DNA ratio. PMID: 19135165
  6. Epistatic analyses suggest a possible genetic interaction between Wnt/beta-catenin and Myostatin in regulation of slow and fast twitch muscle myofibrillogenesis PMID: 19517013

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Subcellular Location
Secreted.
Protein Families
TGF-beta family
Tissue Specificity
Predominantly expressed in muscle. At hatching, expression is strongest in the skin epithelium, and is also found in the retina and brain. From day 28, expressed in skeletal muscle. In the adult, highest expression is seen in the gastrointestinal tract, b
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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