Recombinant Dog Insulin-like growth factor I (IGF1)

Code CSB-YP341443DO
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Source Yeast
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Code CSB-EP341443DO
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Source E.coli
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Code CSB-EP341443DO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP341443DO
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Source Baculovirus
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Code CSB-MP341443DO
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
IGF1
Uniprot No.
Alternative Names
IGF1; IGFIAInsulin-like growth factor I; IGF-I; Somatomedin
Species
Canis lupus familiaris (Dog) (Canis familiaris)
Expression Region
49-118
Target Protein Sequence
GP ETLCGAELVD ALQFVCGDRG FYFNKPTGYG SSSRRAPQTG IVDECCFRSC DLRRLEMYCA PLKPAKSA
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1.
Gene References into Functions
  1. This study suggested that serum 26SP concentrations seem to be increased in some dogs suffering from malignant tumors, especially in dogs with mammary carcinoma and smaller tumors and that increased serum IGF-1 concentrations could be an indication of large tumors and a poor prognosis. PMID: 29755191
  2. Leptin and insulin like growth factor 1 may support spermatogenesis in adult dogs and mediate Leydig cell function PMID: 28101891
  3. This study evaluated the role of IGF1 and phosphoinositol 3 kinase signaling in the pathogenesis of adrenocortical tumors in dogs and to identify pathway components that may hold promise as future therapeutic targets or as prognostic markers. PMID: 25619516
  4. These data strongly indicated a strong relathionship between fetal fluids IGF-I and nonesterified fatty acid concentrations and breed size exists. PMID: 24674237
  5. This study found that serum protein profiles and IGF-I concentrations were altered in both diabetic and insulin-treated animals. PMID: 22122898
  6. There was significantly higher expression of genes encoding for growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in metastases compared to their primary tumours. PMID: 21507690
  7. This study focuses on the co-expression of interleukin-4 (IL-4) and insulin-like-growth factor-1 (IGF-1), which specifically target inflammation and cartilage repair, respectively. PMID: 20188584
  8. variability in height between dogs were associated with dramatic differences in insulin-like growth factor 1(IGF1) and IGF binding protein 3 levels in plasma and follicular fluid and differences were associated with functional aspects of ovarian follicles PMID: 20406781
  9. inhibiting GSK3 increases brain insulin-like growth factor I levels PMID: 20351102
  10. a single IGF1 single-nucleotide polymorphism haplotype is common to all small breeds and nearly absent from giant breeds, suggesting that the same causal sequence variant is a major contributor to body size in all small dogs PMID: 17412960
  11. Genetics are associated with body size in dogs. PMID: 17502080
  12. Study provides evidence that progesteron might increase autocrine Growth Hormone production which might directly stimulate local or systemic IGF-I secretion in canine mammary tumours. PMID: 18367392
  13. IGF-1/IGF-1R and cyclins are involved in the hypertrophic response observed in cardiomyopathies. PMID: 19818143

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Subcellular Location
Secreted.
Protein Families
Insulin family
Database Links
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