Recombinant Dog Apolipoprotein E(APOE)

Product Type Recombinant Protein
Uniprot No. P18649
Species Canis lupus familiaris (Dog) (Canis familiaris)
Gene Names APOE
Protein Names Recommended name: Apolipoprotein E Short name= Apo-E
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Target Details Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
HGNC 613
RGD 2138
MGI 88057
Function Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
Subcellular Location Secreted
Protein Families Apolipoprotein A1/A4/E family
Tissue Specificity Present in multiple tissues including liver, jejunum, urinary bladder, ileum, colon, brain, kidney, spleen, pancreas and testis. Secreted in plasma.
Database Links

STRING: 9615.ENSCAFP00000006888

UniGene: Cfa.16211

Pathway Cholesterol metabolism

Product Details for Different Expression Systems

Product Name Recombinant Dog Apolipoprotein E(APOE),Yeast
Code CSB-YP001936DO
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence DVQPEPELER ELEPKVQQEL EPEAGWQTGQ PWEAALARFW DYLRWVQTLS DQVQEGVLNT QVTQELTALM DETMKEVKAY KAELDEQLGP MTSETQARVA KELQAAQARL RADMEDVRNR LTQYRGELQA MLGQSSEELR ARFASHMRKL RKRVLRDAED LQRRLAVYKA GVREGAERSV SSIRERLWPL LEQARERNAK VGALATQPLL ERADAWGQQL RGQLEEMSSR ARGHLEEMRE QIQEVRVKME EQADQIRQKA EAFQARLKSW FEPLLEDMQR QWDGLVEKVQ AAVATIPTSK PVEEP
Expression Region 1-305
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Dog Apolipoprotein E(APOE),E.coli
Code CSB-EP001936DO
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence DVQPEPELER ELEPKVQQEL EPEAGWQTGQ PWEAALARFW DYLRWVQTLS DQVQEGVLNT QVTQELTALM DETMKEVKAY KAELDEQLGP MTSETQARVA KELQAAQARL RADMEDVRNR LTQYRGELQA MLGQSSEELR ARFASHMRKL RKRVLRDAED LQRRLAVYKA GVREGAERSV SSIRERLWPL LEQARERNAK VGALATQPLL ERADAWGQQL RGQLEEMSSR ARGHLEEMRE QIQEVRVKME EQADQIRQKA EAFQARLKSW FEPLLEDMQR QWDGLVEKVQ AAVATIPTSK PVEEP
Expression Region 1-305
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Dog Apolipoprotein E(APOE),Baculovirus
Code CSB-BP001936DO
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence DVQPEPELER ELEPKVQQEL EPEAGWQTGQ PWEAALARFW DYLRWVQTLS DQVQEGVLNT QVTQELTALM DETMKEVKAY KAELDEQLGP MTSETQARVA KELQAAQARL RADMEDVRNR LTQYRGELQA MLGQSSEELR ARFASHMRKL RKRVLRDAED LQRRLAVYKA GVREGAERSV SSIRERLWPL LEQARERNAK VGALATQPLL ERADAWGQQL RGQLEEMSSR ARGHLEEMRE QIQEVRVKME EQADQIRQKA EAFQARLKSW FEPLLEDMQR QWDGLVEKVQ AAVATIPTSK PVEEP
Expression Region 1-305
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Dog Apolipoprotein E(APOE),Mammalian cell
Code CSB-MP001936DO
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence DVQPEPELER ELEPKVQQEL EPEAGWQTGQ PWEAALARFW DYLRWVQTLS DQVQEGVLNT QVTQELTALM DETMKEVKAY KAELDEQLGP MTSETQARVA KELQAAQARL RADMEDVRNR LTQYRGELQA MLGQSSEELR ARFASHMRKL RKRVLRDAED LQRRLAVYKA GVREGAERSV SSIRERLWPL LEQARERNAK VGALATQPLL ERADAWGQQL RGQLEEMSSR ARGHLEEMRE QIQEVRVKME EQADQIRQKA EAFQARLKSW FEPLLEDMQR QWDGLVEKVQ AAVATIPTSK PVEEP
Expression Region 1-305
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

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