Recombinant Dog Cellular tumor antigen p53 (TP53)

1. These data suggest that the p53 mutant cell line CTBm2 could be a useful tool for analyzing the precise tetramerization mechanisms of p53 and verifying the effects of therapeutic agents against tumors expressing p53 mutants that lack the ability to tetramerize PMID: 29750295
2. Elevation of the tumour suppressor p53 is necessary and sufficient for crowding hypersensitivity in MDCK cell. PMID: 27109213
3. TP53 gene expression alone cannot be considered a marker for tumor aggressiveness in canine mammary carcinomas. PMID: 28754073
4. In all normal samples, p53 was expressed in low number of epithelial cells, while a greater number of positive cells were observed in benign prostatic hyperplasia and prostatic carcinomas. Rb protein was expressed in high number of normal, hyperplastic and neoplastic cells without a statistically significant differences. PMID: 27033932
5. Serum starvation and TdR methods could achieve sufficient synchronization of CHMm cells. Moreover, the expression of p27, p53 and bcl-2 genes was related to cyclical movements and apoptosis. PMID: 27033900
6. Mutations of p53 gene were detected in a proportion of canine lymphoma cells from untreated dogs and can be associated with a poor prognosis. PMID: 26678182
7. p53 knockdown abolished the miR-214-COP1-mediated apoptosis; thus, miR-214 and COP1 regulated apoptosis through controlling p53 in hemangiosarcoma. PMID: 26335793
8. 14-3-3sigma is deregulated in canine TCCs and its expression by highly infiltrative tumor cells may be related to the acquisition of aggressive behavior. PMID: 25979650
9. data suggest that upon inactivating mutation of the p53 gene, mutant p53 acquires its gain of function by altering morphogenesis and promoting cell migration and invasion in part by upregulating EMT and c-Met. PMID: 24386484
10. These results suggest that impaired neurotrophin signaling or compromised trophic support to the retina and p53-mediated apoptosis may not be the underlying mechanism of retinal ganglion cell death in a beagle model of glaucoma. PMID: 22524196
11. identification of the TP53 gene mRNA as well as the expression of p53, Bcl-2 and p63 proteins in histological sections of canine transmissible venereal tumor samples; findings showed the DNA homologous to TP53 and its respective mRNA in 92.3 percent of the samples PMID: 22077405
12. case report, Arg-Gln substitution at codon 248 and CHK2 mutations resulting in multiple primary neoplasms and SIRT1 down-regulation PMID: 21890154
13. Eyelid and third eyelid tumors of dogs express both the p53 and the c-Myc genes as shown by PCR and RT-PCR. PMID: 20447023
14. Four new polymorphisms of TP53 in canine transmissible venereal tumor samples and their groupings are reported. PMID: 19934603
15. The clonal origins of the canine transmissible venereal tumor were studied in relation to the T963C mutation on the tumor protein p53. PMID: 17668284
16. Data show that canine bladder cancer cell lines expressed several proteins of interest associated with bladder cancer prognosis and progression in humans, including p53, cox-2, and pRb protein. PMID: 18562222
17. Mutations of the TP53 gene may influence survival and should be considered when evaluating canine osteosarcoma. PMID: 18986312
18. These data support the notion that the decrease of p63 expression, in particular of its isoform DeltaNp63, seems to be an important factor in the development of carcinomas in mixed tumors. PMID: 19176510
19. Taken together the results suggest that loss of p21 overexpression via its regulator p53 is associated with tumor metastasis while reduced cell cycle inhibition by p27 is associated with malignant progression. PMID: 19185891

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KEGG: cfa:403869

STRING: 9615.ENSCAFP00000024579

UniGene: Cfa.3658