Recombinant Dog Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3(GNB3)

Product Type Recombinant Protein
Uniprot No. P79147
Species Canis lupus familiaris (Dog) (Canis familiaris)
Gene Names GNB3
Protein Names Recommended name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Alternative name(s): Transducin beta chain 3
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Target Details Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described.
HGNC 4400
RGD 708344
MGI 95785
Function Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular Location Cytoplasm, perinuclear region
Protein Families WD repeat G protein beta family
Database Links

KEGG: cfa:403511

STRING: 9615.ENSCAFP00000021609

UniGene: Cfa.5

Pathway Chemokine signaling pathway
PI3K-Akt signaling pathway
Ras signaling pathway
Apelin signaling pathway
Glutamatergic synapse

Product Details for Different Expression Systems

Product Name Recombinant Dog Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3(GNB3),Yeast
Code CSB-YP009606DO
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MGEMEQLRQE AEQLKKQIAD ARKACADTTL AELVSGLEVV GRVQMRTRRT LRGHLAKIYA MHWATDSKLL VSASQDGKLI VWDTYTTNKV HAIPLRSSWV MTCAYAPSGN FVACGGLDNM CSIYSLKSRE GNVKVSRELS AHTGYLSCCR FLDDNNIVTS SGDTTCALWD IETGQQKTVF VGHTGDCMSL AVSPDFKLFI SGACDASAKL WDVREGTCRQ TFTGHESDIN AICFFPNGEA ICTGSDDASC RLFDLRADQE LTAYSDESII CGITSVAFSL SGRLLFAGYD DFNCNIWDSM KGERVGILSG HDNRVSCLGV TADGMAVATG SWDSFLKVWN
Expression Region 1-340
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
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Product Name Recombinant Dog Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3(GNB3),E.coli
Code CSB-EP009606DO
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MGEMEQLRQE AEQLKKQIAD ARKACADTTL AELVSGLEVV GRVQMRTRRT LRGHLAKIYA MHWATDSKLL VSASQDGKLI VWDTYTTNKV HAIPLRSSWV MTCAYAPSGN FVACGGLDNM CSIYSLKSRE GNVKVSRELS AHTGYLSCCR FLDDNNIVTS SGDTTCALWD IETGQQKTVF VGHTGDCMSL AVSPDFKLFI SGACDASAKL WDVREGTCRQ TFTGHESDIN AICFFPNGEA ICTGSDDASC RLFDLRADQE LTAYSDESII CGITSVAFSL SGRLLFAGYD DFNCNIWDSM KGERVGILSG HDNRVSCLGV TADGMAVATG SWDSFLKVWN
Expression Region 1-340
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Dog Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3(GNB3),Baculovirus
Code CSB-BP009606DO
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MGEMEQLRQE AEQLKKQIAD ARKACADTTL AELVSGLEVV GRVQMRTRRT LRGHLAKIYA MHWATDSKLL VSASQDGKLI VWDTYTTNKV HAIPLRSSWV MTCAYAPSGN FVACGGLDNM CSIYSLKSRE GNVKVSRELS AHTGYLSCCR FLDDNNIVTS SGDTTCALWD IETGQQKTVF VGHTGDCMSL AVSPDFKLFI SGACDASAKL WDVREGTCRQ TFTGHESDIN AICFFPNGEA ICTGSDDASC RLFDLRADQE LTAYSDESII CGITSVAFSL SGRLLFAGYD DFNCNIWDSM KGERVGILSG HDNRVSCLGV TADGMAVATG SWDSFLKVWN
Expression Region 1-340
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Dog Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3(GNB3),Mammalian cell
Code CSB-MP009606DO
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MGEMEQLRQE AEQLKKQIAD ARKACADTTL AELVSGLEVV GRVQMRTRRT LRGHLAKIYA MHWATDSKLL VSASQDGKLI VWDTYTTNKV HAIPLRSSWV MTCAYAPSGN FVACGGLDNM CSIYSLKSRE GNVKVSRELS AHTGYLSCCR FLDDNNIVTS SGDTTCALWD IETGQQKTVF VGHTGDCMSL AVSPDFKLFI SGACDASAKL WDVREGTCRQ TFTGHESDIN AICFFPNGEA ICTGSDDASC RLFDLRADQE LTAYSDESII CGITSVAFSL SGRLLFAGYD DFNCNIWDSM KGERVGILSG HDNRVSCLGV TADGMAVATG SWDSFLKVWN
Expression Region 1-340
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

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