Recombinant Dog Heat shock factor protein 4 (HSF4)

Code CSB-YP626195DO
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Source Yeast
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Code CSB-EP626195DO
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Source E.coli
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Code CSB-EP626195DO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP626195DO
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Source Baculovirus
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Code CSB-MP626195DO
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
HSF4
Uniprot No.
Alternative Names
HSF4; Heat shock factor protein 4; HSF 4; Heat shock transcription factor 4; HSTF 4
Species
Canis lupus familiaris (Dog) (Canis familiaris)
Expression Region
1-492
Target Protein Sequence
MQEAPAALPT EPGPSPVPAF LGKLWALVGD PGTDHLIRWS PSGTSFLVSD QSRFAKEVLP QYFKHSNMAS FVRQLNMYGF RKVVSIEQGG LLRPERDHVE FQHPSFVRGR EQLLERVRRK VPALRSDDGR WRPEDLGRLL GEVQALRGVQ EITEARLREL RQQNEILWRE VVTLRQSHGQ QHRVIGKLIQ CLFGPLQTGS SGAGAKRKLS LMLDEGSSCP TPAKFNTCPL PGALLQDPYF IQSPLPETTL GLSSSHRTRG PIISDIHEDS PSPDGTRLSP SSGGRREKGL ALLKEEPASP GGEGEAGLAL APNECDFCVT APPPLSVAVV QAILEGKGNF SPEGPRNAQQ PEPRGPREVP DRGTLGLDRG ARSPENLLPP MLLRAPPESV EPAGPLDVLG PSHQGREWTL MDLDMELSLM QPLGPERSET ELAVKGLNSP GPGKDSTLGA PLLLDVQAAL GGPALSLPGA LTIYSTPESR ANYLGPGANP SP
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
DNA-binding protein that specifically binds heat shock promoter elements (HSE).
Gene References into Functions
  1. Deletion of HSF4 is significantly associated with cataracts and a dog carrying the mutation is approximately 17 times more likely to develop binocular cataracts than dogs that are clear of the mutation. PMID: 19883468
  2. HSF4 is not associated with the development of the late-onset form of cataract and the 2 forms of cataract in Boston Terriers are therefore genetically discrete conditions. PMID: 17611257
  3. Article could not verify that the mutation in exon 9 of canine HSF4 gene is causative for primary cataracts in dog breeds. PMID: 17651328
  4. We found a single nucleotide polymorphism in intron 9 which was neither associated nor linked with the CAT phenotype in the two dog breeds PMID: 18190350
  5. insertion/deletion mutations in exon 9 of heat shock transcription factor 4 are not responsible for juvenile hereditary cataract in Siberian Husky dogs PMID: 18680491

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Involvement in disease
Defects in HSF4 are a cause of forms of hereditary cataract (HC) in dogs. Mutations in HSF4 seem to be causing a recessive form of cataract in Staffordshire Bull terriers and Boston terriers and a dominant cataract in Australian shepherds.
Subcellular Location
Nucleus.
Protein Families
HSF family
Database Links
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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