Recombinant Dog Metalloproteinase inhibitor 1(TIMP1)

Product Type Recombinant Protein
Uniprot No. P81546
Species Canis lupus familiaris (Dog) (Canis familiaris)
Gene Names TIMP1
Protein Names Recommended name: Metalloproteinase inhibitor 1 Alternative name(s): Tissue inhibitor of metalloproteinases 1 Short name= TIMP-1
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Target Details This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.
HGNC 11820
RGD 621675
MGI 98752
Function Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling.
Subcellular Location Secreted
Protein Families Protease inhibitor I35 (TIMP) family
Tissue Specificity Ubiquitously expressed. Highest expression in kidney and ovary.
Database Links

KEGG: cfa:403816

STRING: 9615.ENSCAFP00000022333

UniGene: Cfa.3680

Pathway HIF-1 signaling pathway

Product Details for Different Expression Systems

Product Name Recombinant Dog Metalloproteinase inhibitor 1(TIMP1),Yeast
Code CSB-YP023560DO
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence CTCAPPH PQTALCNSQI VIRAKFVGTA EVNQTDLNRR YEIKMTKMFK GFSALGNASD IRFVDTPALE SVCGYLHRSQ NRSEEFLVAG NLRDGHLQIN TCSFVAPWSS LSTAQRRGFT KTYAAGCEGC TVFTCSSIPC KLQSDTHCLW TDHFLTGSDK GFQSRHLACL PREPGICTWQ SLRPRMA
Expression Region 24-207
Protein Description Full Length of Mature Protein
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Dog Metalloproteinase inhibitor 1(TIMP1),E.coli
Code CSB-EP023560DO
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence CTCAPPH PQTALCNSQI VIRAKFVGTA EVNQTDLNRR YEIKMTKMFK GFSALGNASD IRFVDTPALE SVCGYLHRSQ NRSEEFLVAG NLRDGHLQIN TCSFVAPWSS LSTAQRRGFT KTYAAGCEGC TVFTCSSIPC KLQSDTHCLW TDHFLTGSDK GFQSRHLACL PREPGICTWQ SLRPRMA
Expression Region 24-207
Protein Description Full Length of Mature Protein
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Dog Metalloproteinase inhibitor 1(TIMP1),Baculovirus
Code CSB-BP023560DO
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence CTCAPPH PQTALCNSQI VIRAKFVGTA EVNQTDLNRR YEIKMTKMFK GFSALGNASD IRFVDTPALE SVCGYLHRSQ NRSEEFLVAG NLRDGHLQIN TCSFVAPWSS LSTAQRRGFT KTYAAGCEGC TVFTCSSIPC KLQSDTHCLW TDHFLTGSDK GFQSRHLACL PREPGICTWQ SLRPRMA
Expression Region 24-207
Protein Description Full Length of Mature Protein
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Dog Metalloproteinase inhibitor 1(TIMP1),Mammalian cell
Code CSB-MP023560DO
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence CTCAPPH PQTALCNSQI VIRAKFVGTA EVNQTDLNRR YEIKMTKMFK GFSALGNASD IRFVDTPALE SVCGYLHRSQ NRSEEFLVAG NLRDGHLQIN TCSFVAPWSS LSTAQRRGFT KTYAAGCEGC TVFTCSSIPC KLQSDTHCLW TDHFLTGSDK GFQSRHLACL PREPGICTWQ SLRPRMA
Expression Region 24-207
Protein Description Full Length of Mature Protein
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Still Have Questions? Leave a Message or Start an on-line Chat

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