Recombinant Drosophila melanogaster Serine/threonine-protein kinase fused (fu), partial

1. Data show that normal Ci-155 activation by Hh requires Cos2 binding to Fu, supporting the hypothesis that Cos2 mediates the apposition of Fu molecules suitable for cross-phosphorylation and consequent full activation of Fu kinase. PMID: 25633354
2. Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus. PMID: 21844892
3. Hh-induced Smo conformational change facilitates the assembly of active Smo-Cos2-Fu signaling complexes that promote Fu kinase domain dimerization, phosphorylation and activation; Fu regulates both the activator and repressor forms of Ci PMID: 21852395
4. Study shows that Fused (Fu), a serine/threonine kinase that regulates Hedgehog, functions in concert with the E3 ligase Smurf to regulate ubiquitination and proteolysis of the BMP receptor Thickveins in germline stem cells daughter cystoblasts. PMID: 21145463
5. model in which Hedgehog signals at least twice in germarial somatic cells: through a fused-independent pathway to control somatic stem cell proliferation; and through a classical fused-dependent pathway to regulate prefollicular cell differentiation PMID: 12163413
6. Data show that the Costal2-Fused-Cubitus interruptus (Cos2-Fu-Ci) protein complex is associated with Smoothened (Smo) in membrane fractions, and that Cos2 binding on Smo is necessary for the Hedgehog-dependent dissociation of Ci from this complex. PMID: 14523402
7. Hedgehog signaling requires an intramolecular association between two domains of the protein kinase Fused PMID: 15542847
8. positive role for Fused in the transduction of somatic Hedgehog signaling instructing ovariole morphogenesis PMID: 16145667
9. we provide evidence that fused regulates these cystocyte divisions cell autonomously, while the tumorous phenotype probably reflects both a somatic and germline requirement for fused for cyst and follicle development. PMID: 16516445
10. Findings reveal a novel positive-feedback loop in Hedgehog transduction and support a model in which Fused and SMO enhance each other's activities & sustain high levels of signaling and render the pathway robust to Patched level fluctuations. PMID: 17658259
11. Data suggest that, after activation of Smoothened, the Fused kinase induces a conformational change in Costal2 that allows the disassembly of the Smo-Fu-Cos2-Cubitus interruptus complex and consequent activation of Hedgehog target genes. PMID: 17881487
12. This protein is a component of the Ci signaling complex that regulates Ci nuclear import and cleavage. PMID: 11476581

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KEGG: dme:Dmel_CG6551

STRING: 7227.FBpp0074373