Recombinant Guinea pig Apolipoprotein E(APOE)

Product Type Recombinant Protein
Uniprot No. P23529
Species Cavia porcellus (Guinea pig)
Gene Names APOE
Protein Names Recommended name: Apolipoprotein E Short name= Apo-E
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Target Details Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
HGNC 613
RGD 2138
MGI 88057
Function Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
Subcellular Location Secreted
Protein Families Apolipoprotein A1/A4/E family
Tissue Specificity Secreted in plasma.
Database Links

STRING: 10141.ENSCPOP00000006519

Pathway Cholesterol metabolism

Product Details for Different Expression Systems

Product Name Recombinant Guinea pig Apolipoprotein E(APOE),Yeast
Code CSB-YP001936GU
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence DV EPEVEVREPA VWQSGQPWEL ALSRFWDYLR WVQTLSDQVQ EELLSNQVTQ ELTLLIEDTM KEVKAYKAEL EKELGPVAED TKARLAKELQ AAQARLGADM EEVRNRLSQY RSEVQAMLGQ SSEELRARLT SHPRKMKRRL QRDIDELQKR MAVYKAGAQE GAERGVSAIR ERLGSLIEQG RLQALASQPL QERAQAWGEQ MRGRLEKVGS QARDRLEEVR EQMEEVRVKV EEQAEAFQAR LKSWFEPMME DMRRQWAELI QKVQVAVGAS TSAPSQEP
Expression Region 19-298
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Guinea pig Apolipoprotein E(APOE),E.coli
Code CSB-EP001936GU
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence DV EPEVEVREPA VWQSGQPWEL ALSRFWDYLR WVQTLSDQVQ EELLSNQVTQ ELTLLIEDTM KEVKAYKAEL EKELGPVAED TKARLAKELQ AAQARLGADM EEVRNRLSQY RSEVQAMLGQ SSEELRARLT SHPRKMKRRL QRDIDELQKR MAVYKAGAQE GAERGVSAIR ERLGSLIEQG RLQALASQPL QERAQAWGEQ MRGRLEKVGS QARDRLEEVR EQMEEVRVKV EEQAEAFQAR LKSWFEPMME DMRRQWAELI QKVQVAVGAS TSAPSQEP
Expression Region 19-298
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Guinea pig Apolipoprotein E(APOE),Baculovirus
Code CSB-BP001936GU
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence DV EPEVEVREPA VWQSGQPWEL ALSRFWDYLR WVQTLSDQVQ EELLSNQVTQ ELTLLIEDTM KEVKAYKAEL EKELGPVAED TKARLAKELQ AAQARLGADM EEVRNRLSQY RSEVQAMLGQ SSEELRARLT SHPRKMKRRL QRDIDELQKR MAVYKAGAQE GAERGVSAIR ERLGSLIEQG RLQALASQPL QERAQAWGEQ MRGRLEKVGS QARDRLEEVR EQMEEVRVKV EEQAEAFQAR LKSWFEPMME DMRRQWAELI QKVQVAVGAS TSAPSQEP
Expression Region 19-298
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Guinea pig Apolipoprotein E(APOE),Mammalian cell
Code CSB-MP001936GU
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence DV EPEVEVREPA VWQSGQPWEL ALSRFWDYLR WVQTLSDQVQ EELLSNQVTQ ELTLLIEDTM KEVKAYKAEL EKELGPVAED TKARLAKELQ AAQARLGADM EEVRNRLSQY RSEVQAMLGQ SSEELRARLT SHPRKMKRRL QRDIDELQKR MAVYKAGAQE GAERGVSAIR ERLGSLIEQG RLQALASQPL QERAQAWGEQ MRGRLEKVGS QARDRLEEVR EQMEEVRVKV EEQAEAFQAR LKSWFEPMME DMRRQWAELI QKVQVAVGAS TSAPSQEP
Expression Region 19-298
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

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