Recombinant Guinea pig Ras-related C3 botulinum toxin substrate 1(RAC1)

Product Type Recombinant Protein
Uniprot No. P80236
Species Cavia porcellus (Guinea pig)
Gene Names RAC1
Protein Names Recommended name: Ras-related C3 botulinum toxin substrate 1 Alternative name(s): Sigma 1 component protein p22 p21-Rac1
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Target Details This protein is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene.
HGNC 8590
RGD 3250
MGI 1339975
Function Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. In pituitary cells, may mediate the activation of KCNH2 potassium channel by thyroid hormone (By similarity). Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3 (By similarity).
Subcellular Location Cytoplasm, Membrane, Peripheral membrane protein, Melanosome
Protein Families Small GTPase superfamily, Rho family
Database Links

STRING: 10141.ENSCPOP00000007718

Pathway cAMP signaling pathway
Chemokine signaling pathway
MAPK signaling pathway
PI3K-Akt signaling pathway
VEGF signaling pathway
Wnt signaling pathway
Focal adhesion
Regulation of actin cytoskeleton
Adherens junction
MAPK Erk pathway
Ras signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Natural killer cell mediated cytotoxicity
Osteoclast differentiation
Toll-like receptor signaling pathway
AGE-RAGE signaling pathway in diabetic complications
Rap1 signaling pathway
Sphingolipid signaling pathway
Inhibitors of axonal regeneration
Neurotrophin signaling pathway

Product Details for Different Expression Systems

Product Name Recombinant Guinea pig Ras-related C3 botulinum toxin substrate 1(RAC1),Yeast
Code CSB-YP019242GU
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence AKWYPEVRHH CPNTPIILVG TKLDLRDDKD TIEKLKEKKL TPITYPQGLA MAKEIGAVKY LECSALTQRT VFDEAIR
Expression Region 1-77
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Guinea pig Ras-related C3 botulinum toxin substrate 1(RAC1),E.coli
Code CSB-EP019242GU
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence AKWYPEVRHH CPNTPIILVG TKLDLRDDKD TIEKLKEKKL TPITYPQGLA MAKEIGAVKY LECSALTQRT VFDEAIR
Expression Region 1-77
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Guinea pig Ras-related C3 botulinum toxin substrate 1(RAC1),Baculovirus
Code CSB-BP019242GU
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence AKWYPEVRHH CPNTPIILVG TKLDLRDDKD TIEKLKEKKL TPITYPQGLA MAKEIGAVKY LECSALTQRT VFDEAIR
Expression Region 1-77
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Guinea pig Ras-related C3 botulinum toxin substrate 1(RAC1),Mammalian cell
Code CSB-MP019242GU
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence AKWYPEVRHH CPNTPIILVG TKLDLRDDKD TIEKLKEKKL TPITYPQGLA MAKEIGAVKY LECSALTQRT VFDEAIR
Expression Region 1-77
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

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