Recombinant Hepatitis B virus genotype B2 Protein X(X)

Product Type Recombinant Protein
Uniprot No. P20975
Species Hepatitis B virus genotype B2 (isolate Indonesia/pIDW420/1988) (HBV-B)
Gene Names X
Protein Names Recommended name: Protein X Alternative name(s): HBx Peptide X pX
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Function Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma). Most of cytosolic activities involve modulation of cytosolic calcium. The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted. May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential. May also modulate apoptosis by binding host CFLAR, a key regulator of the death-inducing signaling complex (DISC). Promotes viral transcription by using the host E3 ubiquitin ligase DDB1 to target the SMC5-SMC6 complex to proteasomal degradation. This host complex would otherwise bind to viral episomal DNA, and prevents its transcription. Moderately stimulates transcription of many different viral and cellular transcription elements. Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT.
Subcellular Location Host cytoplasm, Host nucleus, Host mitochondrion
Protein Families Orthohepadnavirus protein X family

Product Details for Different Expression Systems

Product Name Recombinant Hepatitis B virus genotype B2 Protein X(X),Yeast
Code CSB-YP322714HDW
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MAARLCCQLD PARDVLCLRP VGAESRGRPL PGPLGALPPA SPPAVPSDHG AHLSLRGLPV CAFSSAGPCA LRFTSARRME TTVNAHRNLP KVLHKRTLGL SAMSTTDLEA HFKDCVFTEW EELGEEIRLK VFVLGGCRHK LVCSPAPCNF FTSA
Expression Region 1-154
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
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Product Name Recombinant Hepatitis B virus genotype B2 Protein X(X),E.coli
Code CSB-EP322714HDW
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MAARLCCQLD PARDVLCLRP VGAESRGRPL PGPLGALPPA SPPAVPSDHG AHLSLRGLPV CAFSSAGPCA LRFTSARRME TTVNAHRNLP KVLHKRTLGL SAMSTTDLEA HFKDCVFTEW EELGEEIRLK VFVLGGCRHK LVCSPAPCNF FTSA
Expression Region 1-154
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Hepatitis B virus genotype B2 Protein X(X),Baculovirus
Code CSB-BP322714HDW
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MAARLCCQLD PARDVLCLRP VGAESRGRPL PGPLGALPPA SPPAVPSDHG AHLSLRGLPV CAFSSAGPCA LRFTSARRME TTVNAHRNLP KVLHKRTLGL SAMSTTDLEA HFKDCVFTEW EELGEEIRLK VFVLGGCRHK LVCSPAPCNF FTSA
Expression Region 1-154
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Hepatitis B virus genotype B2 Protein X(X),Mammalian cell
Code CSB-MP322714HDW
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MAARLCCQLD PARDVLCLRP VGAESRGRPL PGPLGALPPA SPPAVPSDHG AHLSLRGLPV CAFSSAGPCA LRFTSARRME TTVNAHRNLP KVLHKRTLGL SAMSTTDLEA HFKDCVFTEW EELGEEIRLK VFVLGGCRHK LVCSPAPCNF FTSA
Expression Region 1-154
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

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