Recombinant Human ATP-binding cassette sub-family A member 2 (ABCA2), partial

Code CSB-YP887172HU
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Source Yeast
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Code CSB-EP887172HU
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Source E.coli
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Code CSB-EP887172HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP887172HU
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Source Baculovirus
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Code CSB-MP887172HU
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
ABCA2
Uniprot No.
Alternative Names
ABC2; Abca2; ABCA2_HUMAN; ATP binding cassette 2; ATP binding cassette sub family A member 2; ATP binding cassette transporter 2; ATP binding cassette; sub family A (ABC1); member 2; ATP binding cassette; sub family A; member 2; ATP binding cassette; sub family B (MDR/TAP); member 2; ATP-binding cassette 2; ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes. In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP. May play a role in myelin formation.
Gene References into Functions
  1. The analyses results suggested ABCA2 mRNA expression was upregulated significantly in AD compared with controls in all datasets. PMID: 29224028
  2. Our findings indicate a considerable and direct relationship between mRNA expression levels of ABCA2, ABCA3, MDR1, and MRP1 genes and positive minimal residual disease (MRD) measured after one year of treatment. PMID: 24145140
  3. Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-beta production by altering Nicastrin maturation and intracellular localization. PMID: 22086926
  4. SLC2A1/GLUT1, SLC1A3/EAAT1, and SLC1A2/EAAT2 were the main SLC proteins whereas ABCG2/BCRP, ABCB1/MDR1, ABCA2 and ABCA8 were the main ABC quantified in isolated brain microvessels PMID: 21707071
  5. A possible biochemical mechanism links ABCA2 expression, amyloid precursor protein processing, and Alzheimer's disease. PMID: 20704561
  6. we demonstrate that ABCA2-deficiency inhibits prostate tumor metastasis in vivo and decreases chemotactic potential of cells PMID: 21041019
  7. roles for this largest known ABC protein in neural transmembrane lipid export PMID: 12363033
  8. Reciprocal regulation of expression of the ABCA2 promoter by the early growth response-1 and Sp-family transcription factors. PMID: 12560508
  9. It is likely that expression of ABCA2 by two independent promoters constitutes locus of regulation controlling expression of the protein to meet requirements in different tissues. PMID: 15093135
  10. Increased expression of ABCA2 may be causally linked with altered expression of genes associated with the pathogenesis of Alzheimer disease. PMID: 15155565
  11. Among the 45 ABCA2 single nucleotide polymorphisms(SNPs) we tested, one synonymous SNP (rs908832) was found significantly associated with AD in both samples. PMID: 15649702
  12. the expression patterns of ABCA2 in combination with other markers showed phenotypic heterogeneity in schwannomas PMID: 15850583
  13. Data suggest that ABCA2 may exert population-dependent effects on the genetic risk for sporadic Alzheimer's disease and support a role of ABC lipid transporters in the pathogenesis of this disease. PMID: 16752360
  14. No association of ABCA2 Single Nucleotide Polymorphism on chromosome 9 with Alzheimer's disease. PMID: 18336955

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Subcellular Location
Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Protein Families
ABC transporter superfamily, ABCA family
Tissue Specificity
[Isoform 3]: Highly expressed in the brain,peripheral blood leukocytes and ovary, whereas lower levels of expression is observed in kidney and liver.; [Isoform 4]: Weakly expressed in brain and highly in peripheral blood leukocytes.
Database Links

HGNC: 32

OMIM: 600047

KEGG: hsa:20

STRING: 9606.ENSP00000344155

UniGene: Hs.421202

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