Recombinant Human Biorientation of chromosomes in cell division protein 1 (BOD1)

Code CSB-YP846637HU
MSDS
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Source Yeast
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Code CSB-EP846637HU
MSDS
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Source E.coli
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Code CSB-EP846637HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP846637HU
MSDS
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Source Baculovirus
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Code CSB-MP846637HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
BOD1
Uniprot No.
Alternative Names
BOD1; FAM44BBiorientation of chromosomes in cell division protein 1; Biorientation defective protein 1; Protein FAM44B
Species
Homo sapiens (Human)
Expression Region
1-185
Target Protein Sequence
MADGGGGGGT GAVGGGGTSQ ASAGAATGAT GASGGGGPIN PASLPPGDPQ LIALIVEQLK SRGLFDSFRR DCLADVDTKP AYQNLRQKVD NFVSTHLDKQ EWNPTMNKNQ LRNGLRQSVV QSGMLEAGVD RIISQVVDPK LNHIFRPQIE RAIHEFLAAQ KKAAVPAPPP EPEGQDPPAP SQDTS
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.
Gene References into Functions
  1. Kinetochore targeting of Bod1 depends on Ndc80 and not PP2A-B56. Bod1 depletion functionally affects Ndc80 phosphorylation at S55. PMID: 29142109
  2. these results suggest that radiation alters miR-142-3p and Bod1 expression in carcinoma cells, and thus contributes to early stages of radiation-induced genomic instability PMID: 27527863
  3. we established two Drosophila models, where neuron-specific knockdown of BOD1 caused pronounced learning deficits and significant abnormalities in synapse morphology. Together our results reveal novel postmitotic functions of BOD1 as well as pathogenic mechanisms that strongly support a causative role of BOD1 deficiency in the aetiology of intellectual disability. PMID: 27166630
  4. Bod1 regulates protein phosphatase 2A at mitotic kinetochores. PMID: 24157919
  5. Bod1 is a novel kinetochore protein that is required for the detection or resolution of syntelic attachments in mitotic spindles. PMID: 17938248
  6. siRNA depeletion of Fam44B (named Bod1 - Biorientation Defective 1 in this publication) resulted in persistent chromosome congression defects in metaphase. PMID: 17938248

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Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Note=Localizes at the centrosomes throughout the cell cycle, only dissociating during cytokinesis. Localizes at the kinetochore from prometaphase until anaphase.
Protein Families
BOD1 family
Database Links

HGNC: 25114

OMIM: 616745

KEGG: hsa:91272

STRING: 9606.ENSP00000309644

UniGene: Hs.425091

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