Recombinant Human Calcium/calmodulin-dependent protein kinase II inhibitor 2 (CAMK2N2)

Code CSB-YP004470HU
MSDS
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Source Yeast
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Code CSB-EP004470HU
MSDS
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Source E.coli
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Code CSB-EP004470HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP004470HU
MSDS
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Source Baculovirus
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Code CSB-MP004470HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
CAMK2N2
Uniprot No.
Alternative Names
CAMK2N2Calcium/calmodulin-dependent protein kinase II inhibitor 2; CaM-KII inhibitory protein; CaM-KIIN
Species
Homo sapiens (Human)
Expression Region
1-79
Target Protein Sequence
MSEILPYSED KMGRFGADPE GSDLSFSCRL QDTNSFFAGN QAKRPPKLGQ IGRAKRVVIE DDRIDDVLKG MGEKPPSGV
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca(2+)/calmodulin on CAMK2.
Gene References into Functions
  1. Mutant FUS-DeltaNLS increased calcium/calmodulin-dependent protein kinase II inhibitor 2 (CAMK2N2) at both mRNA and protein levels. PMID: 23545117
  2. Murine double minute 2 (MDM2) protein levels were decreased in AD cells relative to control lymphoblasts, suggesting an impairment of FOXO3a degradation. PMID: 23153928
  3. We show that CaMKII N beta expression is differentially regulated by novelty and contextual fear conditioning, providing further insight into molecular basis of fear LTM. PMID: 20487031
  4. hCaMKIINbeta may play an important role in the regulation of tumor cell growth PMID: 19586909
  5. Functional study of the rat homolog PMID: 9724800

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Subcellular Location
Nucleus. Cytoplasm, cytosol.
Protein Families
CAMK2N family
Tissue Specificity
Expressed in cell lines including hemopoietic cell lines and some tumor cell lines. Highly Expressed in stimulated dendritic cell (DC) and weakly expressed in unstimulated mature and immature DC. Highly expressed in kidney, liver, in cell lines HeLaS3, ly
Database Links

HGNC: 24197

OMIM: 608721

KEGG: hsa:94032

STRING: 9606.ENSP00000296238

UniGene: Hs.585003

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