Recombinant Human Caspase-5(CASP5),partial

Code CSB-YP004550HU
Product Type Recombinant Protein
Size US$2010
Uniprot No. P51878
Relevance Mediator of programmed cell death (apoptosis).
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Storage Buffer Tris-based buffer,50% glycerol
Alias ICE(rel)-III Protease ICH-3 Protease TY Cleaved into the following 2 chains: Caspase-5 subunit p20 Caspase-5 subunit p10
Species Homo sapiens (Human)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence DQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRD
Research Area Cell Biology
Source Yeast
Gene Names CASP5
Protein Names Recommended name: Caspase-5 Short name= CASP-5 EC= 3.4.22.58 Alternative name(s): ICE(rel)-III Protease ICH-3 Protease TY Cleaved into the following 2 chains: 1. Caspase-5 subunit p20 2. Caspase-5 subunit p10
Expression Region 137-327aa
Tag Info N-terminal 6xHis-tagged
Mol. Weight 23.8kDa
Protein Description Partial
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Mediator of programmed cell death (apoptosis). During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation
Protein Families Peptidase C14A family
Tissue Specificity Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle.
Database Links

HGNC: 1506

OMIM: 602665

KEGG: hsa:838

STRING: 9606.ENSP00000376849

UniGene: Hs.213327

Pathway NOD-like receptor signaling pathway

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