Recombinant Human Caspase recruitment domain-containing protein 11 (CARD11), partial

1. CARMA1 forms CARMA1-BCL10-MALT1-TRAF6 signalosome.CARMA1, the BCL10 nucleator, serves as a hub for formation of star-shaped filamentous networks of BCL10 and significantly decreases the lag period of BCL10 polymerization. PMID: 29382759
2. study results suggest variations in the inflammasome, particularly in NLRP1 and CARD11, may be associated with chronic Chagas cardiomyopathy PMID: 29438387
3. CARD11, a scaffold protein required for B-cell receptor (BCR)-induced NF-kappaB activation, was screened in an additional 173 MCL samples and mutations were observed in 5.5% of cases. PMID: 27224912
4. CARMA1 may be aberrantly upregulated in T-ALL, leading to disease progression and migration of leukemic cells to the CNS PMID: 27698445
5. findings indicate that a single hypomorphic mutation in CARD11 can cause potentially correctable cellular defects that lead to atopic dermatitis PMID: 28628108
6. NF-kappaB and beta-catenin signaling by gain-of-function mutations in CARMA1 augments WNT stimulation and is required for regulating the expression of distinct NF-kappaB target genes to trigger cell-intrinsic and extrinsic processes that promote DLBCL lymphomagenesis PMID: 26776161
7. CARD11 mutations are rare in patients with CD5+ DLBCL. PMID: 27915469
8. results define molecular determinants that control the production of Lin(Ub)n-Bcl10, an important signaling intermediate in TCR and oncogenic CARD11 signaling. PMID: 27777308
9. We evaluated the relationship between rs4722404 polymorphism in the CARD11 gene, and the risk and clinical features of psoriasis vulgaris in a southern Chinese Han cohort.We identified no association between the SNP and risk of psoriasis vulgaris. PMID: 27421022
10. single amino acid oncogenic CARD11 mutations can perturb or bypass the action of redundant inhibitory REs to achieve the level of hyperactive CARD11 signaling required to support lymphoma growth. PMID: 26884334
11. Cooperative Control of Caspase Recruitment Domain-containing Protein 11 (CARD11) Signaling by an Unusual Array of Redundant Repressive Elements. PMID: 26884335
12. CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas. PMID: 26747248
13. Data show that caspase recruitment domain-containing protein 11/B-cell CLL/lymphoma 10/mucosa-associated lymphoid tissue lymphoma translocation gene 1 signaling drives lymphoproliferation through NF-kappa B and c-Jun N-terminal kinase activation. PMID: 26668357
14. CARD11-mediated alterations in NF-kappaB signaling may be an early event in the development of cutaneous squamous cell carcinoma PMID: 26212909
15. Taken together, our data indicate that miR-539 is a novel regulator of migration and invasion in human thyroid cancer cells by targeting CARMA1. PMID: 26206083
16. CARMA1 clustering through SH3-GUK domain interactions is required for its activation of NF-kappaB signalling PMID: 25602919
17. Both carried homozygous germline mutations in CARD11 (p.Cys150*), impairing NF-kappaB signaling and IL-2 production PMID: 26289640
18. Three patients have been described with mild B-cell lymphocytosis and a CARD11 C49Y missense mutation. PMID: 25930198
19. Overexpression of CARMA-BCL10-MALT in T-ALL may contribute to the constitutive cleavage and inactivation of A20, which enhances NF-kappaB signaling and may be related to T-ALL pathogenesis. PMID: 25384343
20. Data indicate that caspase recruitment domain family, member 11 protein CARD11 has complex 5'UTRs and is sensitive to eIF4A RNA helicase inhibition. PMID: 25320244
21. Data indicate that caspase recruitment domain membrane-associated guanylate kinase protein 1 (CARMA1)-silenced cells K562/shCARMA 1-93 showed the greatest inhibition of CARMA 1 gene and protein expressions. PMID: 25001930
22. CKIP-1 interacts with CARMA1 and has an inhibitory effect on PKCtheta;-CBM-NF-kappaB signaling. PMID: 24465689
23. Data indicate that phosphorylation of Carma1 down-stream of TCR/CD28-dependent NF-kappaB induction is regulated in part by Akt. PMID: 24548923
24. CARMA1 CARD was then purified to homogeneity and crystallized at 293 K. Finally, X-ray diffraction data were collected to a resolution of 3.2 A from a crystal belonging to space group P2(1)2(1)2(1) PMID: 23545653
25. Combining crystallography, nuclear magnetic resonance, and electron microscopy, we reveal the structure of the Bcl10 CARD filament and the mode of interaction between CARMA1 and Bcl10 PMID: 24074955
26. SMO activates trimeric G proteins and CARMA1-associated signaling complex, leading to NF-kappaB activation and results in diffuse large B-cell lymphoma. PMID: 23632891
27. distinct CARMA1-dependent control of key cell cycle proteins in T cells is coordinated by ADAP PMID: 22411628
28. In patients with CARD11 deficiency, the combination of impaired activation and especially upregulation of inducible T-cell costimulator on T cells. PMID: 23374270
29. These data provide the first evidence that ubiquitination of CARMA1 by STUB1 promotes TCR-induced NF-kappaB signaling. PMID: 23322406
30. CARD11 gain-of-function mutations selectively confer the ability to associate with Bcl10 and induce K63-linked ubiquitination of Bcl10. PMID: 23149938
31. The incidence of CARD11 mutations was 10.7% in Middle Eastern diffuse large B-cell lymphoma. PMID: 22397314
32. Findings show that regulation of CARD11 signaling is a critical switch governing the decision between death and proliferation in antigen-stimulated mature B cells. PMID: 23027925
33. CARD11 mutations may predispose to B but not T lymphoid malignancy. PMID: 23129749
34. The present study failed to find any mut-ation in MYD88, CARD11 or CD79B in ocular MALT lymphoma. PMID: 22808296
35. PKCdelta is a negative regulator in T cell activation through inhibiting the assembly of CARMA1 signalosome. PMID: 22528498
36. TLR-dependent TRAF6-MKK3-p38 MAPK signaling pathway synergizes with PKCtheta;-MEK-ERK signaling pathway. CARMA1 plays a crucial role in mediating this synergistic effect via TRAF6. PMID: 22303480
37. In Jurkat cells, CARMA1 is required for induction of Th2 transcription factors, GATA3 and JunB, and controls IL-4, IL-5, and IL-10 production. PMID: 22371397
38. expression of CARMA1 mRNA is likely associated with the expression of MUM1 and shows male predominance in diffuse large B cell lymphoma. PMID: 21569705
39. A combination of in vitro and in vivo studies demonstrates that the CARMA1 transgene is required for optimal T cell responses to T cell receptor engagement and development of allergic airway inflammation, after activation of T cells in a murine model. PMID: 22075698
40. genetic polymorphism is associated with common variable immunodeficiency PMID: 21905497
41. Very low mutation frequency of exons 5-9 in the CARD11 gene from 186 adult acute leukemia and 31 multiple myeloma samples. PMID: 21176849
42. PP2A-mediated dephosphorylation of Carma1 is a critical step to limit T-cell activation and effector cytokine production. PMID: 21157432
43. CARM1 is transcriptional coactivators that deposit H3R17me2a and H4R3me2a marks, respectively. PMID: 21172665
44. results establish a mechanism that explains how diffuse large B cell lymphoma-associated mutations in CARD11 can initiate spontaneous, receptor-independent activation of NF-kappaB PMID: 20799731
45. The mutations of the oncogene CARD11 may contribute to NF-kappaB activation and thereby play a role in the pathogenesis of Primary CNS lymphoma. PMID: 20544211
46. the ADAP CARMA1 binding site is required for IKK gamma ubiquitination; both TAK1 and CARMA1 binding sites are required for IkappaB alpha phosphorylation and degradation and NF-kappaB nuclear translocation PMID: 20164171
47. CARMA1 is an essential signaling component that mediates TCR-induced NF-kappa B activation. PMID: 12154356
48. CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation and CD28 costimulation-dependent Jnk activation. PMID: 12154360
49. CARMA1 and CARMA3 bind to Ikappa kinase gamma-NFkappaB in B and T lymphocytes PMID: 15184390
50. Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation. PMID: 16356856

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HGNC: 16393

OMIM: 607210

KEGG: hsa:84433

STRING: 9606.ENSP00000380150

UniGene: Hs.648101