Recombinant Human Chitinase-3-like protein 1(CHI3L1)

Code CSB-YP005346HU
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Source Yeast
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Code CSB-EP005346HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP005346HU
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Source Baculovirus
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Code CSB-MP005346HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names CHI3L1
Uniprot No. P36222
Alternative Names 39 kDa synovial protein; ASRT7; Cartilage glycoprotein 39; CGP-39; CGP39; CH3L1_HUMAN; CHI3L1; chitinase 3 like 1 (cartilage glycoprotein 39) ; chitinase 3 like 1; Chitinase 3 like protein 1 precursor ; chitinase; Chitinase-3-like protein 1; Chondrocyte protein YKL40; GP 39; GP-39; GP39; HC gp39 ; HCGP 3P ; hCGP-39; HCgp39; YKL 40; YKL-40; YKL40; YYL 40
Species Homo sapiens (Human)
Expression Region 22-383
Target Protein Sequence YKLVCYYTS WSQYREGDGS CFPDALDRFL CTHIIYSFAN ISNDHIDTWE WNDVTLYGML NTLKNRNPNL KTLLSVGGWN FGSQRFSKIA SNTQSRRTFI KSVPPFLRTH GFDGLDLAWL YPGRRDKQHF TTLIKEMKAE FIKEAQPGKK QLLLSAALSA GKVTIDSSYD IAKISQHLDF ISIMTYDFHG AWRGTTGHHS PLFRGQEDAS PDRFSNTDYA VGYMLRLGAP ASKLVMGIPT FGRSFTLASS ETGVGAPISG PGIPGRFTKE AGTLAYYEIC DFLRGATVHR ILGQQVPYAT KGNQWVGYDD QESVKSKVQY LKDRQLAGAM VWALDLDDFQ GSFCGQDLRF PLTNAIKDAL AAT
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.
Gene References into Functions
  1. YKL-40 elevation significantly improved risk prediction for all-cause and cardiovascular mortality in hemodialysis patients. PMID: 28941940
  2. Polymorphisms of the CHI3L1 gene (rs4950928 C>G and rs10399931 C>T) are associated with the risk and prognosis of AD and can affect the expression of CHI3L1 in plasma. PMID: 30223258
  3. High YKL-40 expression is associated with endothelial cell angiogenesis in breast cancer. PMID: 29274508
  4. Pretreatment serum levels of YKL-40 may be a novel prognostic factor of overall and disease-free survival in patients with nonmetastatic colorectal cancer PMID: 29642772
  5. Plasma YKL-40 distinguishes between patients with features of asthma-chronic obstructive pulmonary disorder (COPD) overlap (ACO) and COPD patients. PMID: 29580282
  6. CHI3L1 expression is a novel biomarker for the prognosis of gastric cancer and these findings have thus identified CHI3L1/CD44 axis as a vital pathway and potential therapeutic target in gastric cancer PMID: 30165890
  7. YKL-40 was highly elevated in patients with ESRD on HD, and dialysis reduced serum YKL-40 concentrations approximately one-sixth. YKL-40 measured after dialysis was independently associated with mortality in HD patients. PMID: 29357700
  8. Review/Meta-analysis: YKL-40 may be implicated in bronchial inflammation and remodeling in COPD and may be considered as a useful biomarker for COPD diagnosis and monitoring. PMID: 29430175
  9. YKL-40 is a glycoprotein - a potential marker for active inflammatory process - with proven predictive value in a number of diseases that evolve with inflammation, remodeling of the extracellular matrix, or development of fibrosis. PMID: 29400369
  10. TMEM219 plays a critical role in Chi3l1-induced IL-13Ralpha2 mediated signalling and tissue responses. PMID: 27629921
  11. Our present data reveal the crucial role of CHI3L1 in the formation of vasculogenic mimicry, which may contribute to tumour aggressiveness of cervical cancer PMID: 29452694
  12. there was a negative correlation between YKL-40 and TLR4 expression in chronic sinusitis patients with nasal polyps. YKL-40 and TLR4 interacted with each other to activate NF-kappaB and promote disease progression. PMID: 29921378
  13. CHI3L1 may be a previously unrecognized biomarker for diagnosing Gaucher Diseases (GD) and for evaluating the therapeutic effects of new GD drug. PMID: 29396296
  14. Study established a connection between the pretreated CHI3L1 and patients with esophageal squamous cell carcinoma (ESCC), and the serum CHI3L1 was primarily secreted by ESCC-surrounded macrophages. PMID: 29209110
  15. YKL-40 is expressed in cutaneous Squamous Cell Skin Cancer PMID: 30061245
  16. The G allele of CHI3L1 rs4950928 might be a protective factor against the development of asthma. PMID: 29233108
  17. This study suggests that CHI3L1 and CHI3L2 are associated with the progression of neurodegeneration in motor cortex and spinal cord of Amyotrophic Lateral Sclerosis patients. PMID: 28989002
  18. in neurodegenerative dementias, YKL-40 is a disease-specific marker of neuroinflammation showing its highest levels in prion diseases PMID: 29126445
  19. Serum IL-6, serum YKL-40, and plasma VEGF were significantly correlated with disease activity at baseline in early rheumatoid arthritis. PMID: 29336711
  20. high serum YKL-40 levels correlated with the severity of obstructive sleep apnea syndrome and might serve as a nonspecific biomarker for prediction and progression of the disease. PMID: 29028081
  21. YKL-40 could be considered as a useful biomarker of inflammation in psoriasis and is more sensitive than CRP or WBC. Increased YKL-40 may indicate psoriatic patients with a higher level of systemic inflammation, which may determine disease management. PMID: 28932021
  22. YKL-40 protein expression associated with severe lung function impairment and severe exacerbations in Asthma patients. PMID: 29025889
  23. Results suggest a potential role of chitinase 3 like 1 protein (CHI3L1) in angiogenesis in invasive ductal breast carcinoma (IDC) and may suggest its involvement in cancer progression. PMID: 29848684
  24. YKL-40 is a promising biomarker for evaluating polymyositis/dermatomyositis-associated interstitial lung disease activity/severity and predicting disease prognosis. PMID: 28711881
  25. Early-onset atopic dermatitis was associated with rs2303067 in SPINK5, which is involved in skin barrier functioning, and late-onset was associated with rs4950928 in CHI3L1, which is involved in the immune response. Future studies should examine the early- versus late-onset subgrouping more closely. PMID: 28681574
  26. YKL-40 may represent a novel biomarker for predicting hypertension risk in prehypertension population PMID: 28797750
  27. A high diagnostic sensitivity of YKL-40 in the early stages of the disease suggests the possibility of using this biomarker at an early diagnostic phase of patients with endometrial cancer. The patients with increased levels of YKL-40 before treatment are also at the higher risk of relapse. PMID: 28624692
  28. Serum YKL-40 was elevated only in atrial fibrllation and not in other supraventricular arrhythmias. PMID: 28639986
  29. YKL-40 is elevated in serum and bronchoalveolar lavage fluid of pulmonary alveolar proteinosis (PAP) patients, and may be of clinical utility to predict outcome in PAP PMID: 28569052
  30. strongly expressed in placenta percreta and correlated with extravillous trophoblast invasion PMID: 27977409
  31. YKL-40 was expressed by macrophages in liver tissue of NAFLD patients. PMID: 27739482
  32. The results of this study indicate that YKL-40 may contribute to decreased stability and increased permeability of BBB in AD patients PMID: 28697565
  33. YKL-40 is expressed by a subset of astrocytes in Alzheimer's disease and other tauopathies. PMID: 28599675
  34. This study has shown that YKL-40 serum level is increased in patients with atopic dermatitis and reflects the severity of symptoms. PMID: 28660216
  35. YKL-40 levels were found to be significantly higher in post-infectious bronchiolitis obliterans (PIBO) patients with exacerbation compared with that in bronchiolitis patients and showed a positive correlation with the severity of disease before diagnosis of PIBO. PMID: 28567534
  36. miR-24 serves as a molecular regulator in S. aureus-induced macrophage polarization through targeting of CHI3L1 and regulation of the MAPK pathway PMID: 28303416
  37. High YKL-40 expression is independently and markedly associated with worse overall survival in glioblastoma patients. PMID: 27090900
  38. Datashow that patients with YKL-40 overexpression had significantly shorter survival time than those with low YKL-40 expression. PMID: 28099248
  39. The level of serum YKL-40 is a significant and independent biomarker to predict the clinical outcome in large-artery atherosclerotic stroke. PMID: 27650381
  40. TrkB-containing exosomes play a key role in the control of glioblastoma progression and aggressiveness, as seen in a model of YKL-40-inactivated glioblastoma cells PMID: 27385098
  41. findings suggest that these pulmonary markers could be useful to assess CAP severity and, especially YKL-40 and CCL18 by helping predict CAP caused by atypical pathogens PMID: 29324810
  42. The present meta-analysis indicate that elevated YKL-40 expression is associated with a poor prognosis in breast cancer patients. YKL-40 may serve as a promising predictive biomarker of prognosis of breast cancer PMID: 28036271
  43. YKL-40 induces IL-18 production in osteoblasts and thereby stimulates angiogenesis of endothelial progenitor cells through the suppression of miR-590-3p via the focal adhesion kinase (FAK)/PI3K/Akt signaling pathway. PMID: 28448439
  44. YKL-40 levels showed a positive correlation with blood neutrophil counts but no consistent relationships with clinical characteristics of relevance to continuous wheeze in preschool children PMID: 27732738
  45. Study suggests that YKL-40 is associated with hypertension incidence only among men. PMID: 27815265
  46. In HCT donors with YKL-40 plasma concentrations, a trend toward increased grade II-IV acute GvHD in recipients was observed with no significant associations with overall survival, treatment-related mortality or relapse PMID: 27427920
  47. Review of evidence for the role of YKL-40 in the diagnosis, prognosis and cause of cardiovascular and alcoholic liver disease. PMID: 27187575
  48. the level of CHI3L1 protein in the sera of patients with gastric or breast cancer was significantly elevated compared with those of healthy donors. M2 macrophage-secreted CHI3L1 promoted the metastasis of gastric and breast cancer cells in vitro and in vivo PMID: 28143526
  49. Besides being associated with tau pathology, CSF YKL-40 adds to the growing array of biomarkers reflecting distinct molecular brain mechanisms potentially useful for stratifying individuals for biomarker-guided, targeted anti-inflammatory therapies emerging from precision medicine. PMID: 28281838
  50. SNPs in CHI3L1 and cord blood YKL-40 were not associated with lung function measurements at 5 weeks and 6 years, respiratory symptoms in the first year, and allergic sensitisation at 6 years. Genetic variation in CHI3L1 might be related to the development of milder forms of asthma. PMID: 27193312
  51. Increased serum YKL-40 was related with poor collateral development and high SYNTAX score in patients with coronary artery disease. PMID: 27668705
  52. Plasma YKL-40 and IL-6 had less diagnostic impact than CA 19.9 PMID: 23840582
  53. Findings show high level of both YKL-40 and GAP-43 in CSF of older women with suicidal ideation which suggest that a disrupted synaptic glial functioning and inflammation may be related to the aetiology of suicidal ideation in older adults. PMID: 28211584
  54. fibroblast-derived Chi3L1 as a novel key player in the complex reciprocal interactions of stromal cells that facilitate tumor progression and metastasis. PMID: 28368410
  55. Findings suggest that elevated serum YKL-40 levels are associated with the existence of uterine leiomyomas, and YKL-40 might be a potential adjunct biomarker for diagnosis of uterine leiomyomas. PMID: 27170664
  56. Collagen binds in two locations at the YKL-40 surface, potentially related to a role in fibrillar formation. Finally, heparin non-specifically binds at the YKL-40 surface, as predicted from structural studies PMID: 28053085
  57. This is the first report on the association between low-frequency and common variants in the chitinases-related genes CHIA and CHI3L1 with the intensity of specific IgE to ABA-1 in a population naturally exposed to Ascaris and with Bet v 1 in a Swedish population. PMID: 27977724
  58. results indicate that patients with CHI3L1 rs880633 variant genotypes TC+CC are at a higher risk of HCC. CHI3L1 polymorphisms rs880633 or rs4950928 may be potential candidates for predicting poor HCC prognosis and clinical status. PMID: 28260989
  59. High YKL-40 levels were associated with a 2-fold increased risk of venous thromboembolism, but the association was not causal. PMID: 26988593
  60. 83 preterm infants with Bronchopulmonary dysplasia born <28-wk gestation and still inpatients at 36-wk corrected age received an echocardiogram and blood tests of B-type natriuretic peptide (BNP), troponin I, and YKL-40. PMID: 27760764
  61. Serum YKL-40 levels were increased in rheumatoid arthritis patients compared to controls. The highest levels were found in synovial fluid. PMID: 28384116
  62. this study shows that CHI3L1 levels in donor cells may be related to the risk of acute graft-versus-host disease and targeting CHI3L1 may be a promising clinical strategy to control acute graft-versus-host disease PMID: 28324830
  63. The study showed that serum YKL-40 levels were signi fi cantly elevated in patients with moderate and severe asthma compared with reference group. Although there was a positive correlation with disease severity, the study did not suggest serum YKL-40 to be a diagnostic marker of mild asthma as the difference in levels of serum YKL-40 between reference and mild asthma group was not found to be statistically signi fi cant. PMID: 27616735
  64. This study shown that GHI3L1 is regulated differently in healthy and late-onset Alzheimer disease brain depending on the sex. PMID: 27653898
  65. YKL-40 concentration in the serum of Kawasaki disease (KD) patients significantly increased during the acute disease phase compared with those of disease controls and healthy controls. Increased YKL-40 levels may provide a useful inflammatory marker for patients with KD PMID: 27881022
  66. CHI3L1 is associated with tumor metastasis and might be a prognostic biomarker for papillary thyroid carcinoma. PMID: 28009325
  67. YKL-40 expression was observed in 45 (58.4%) of 77 SVZ type II Glioblastomas (GBs) and in 17 (22.6%) of 75 SVZ type III GBs PMID: 27179219
  68. Independent validation with glioma patients tissue (n = 70) and normal brain tissue (n = 19) found PPIC, EMP3 and CHI3L1 were up-regulated in glioma tissue. Survival value validation showed that the three genes correlated with patient survival by Kaplan-Meir analysis, including grades, age and therapy. PMID: 27801851
  69. Time-dependent increase of chitinase1 in APP/PS1 double transgenic mice indicates that the level of chitinase1 is associated with decline of cognition. PMID: 26935740
  70. CHI3L1-mediated cell proliferation/survival involves partial downregulation of the pro-apoptotic S100A9 protein that is highly expressed during the acute phase of colitis, by binding to the S100A9 receptor, RAGE (Receptor for Advanced Glycation End products). PMID: 26431492
  71. Glycoprotein YKL-40 could be considered a biomarker of chronic graft-vs-host disease severity and activity PMID: 27374825
  72. High expression of YKL40 is associated with cholangiocarcinoma. PMID: 26781979
  73. Polymorphism in the CHI3L1 rs4950928 C allele is associated with rectal cancer. PMID: 26779637
  74. Unexpectedly and contrary to some other findings in cancer tissues, this study has shown a correlation between high YKL-40 tumor cell/matrix ratio and longer overall survival in human osteosarcoma. PMID: 26988273
  75. Data show that calcitriol and lysophosphatidic acid converge to enhance chitinase-3-like protein 1 (YKL-40) production by osteosarcoma-derived osteoblast, MG63. PMID: 27575987
  76. Serum YKL-40 level seems to be unuseful for monitoring the effect of treatment in knee osteoarthritis. PMID: 25955771
  77. Gingival crevicular fluid YKL-40 level was elevated in periodontitis, but not diabetes mellitus . YKL-40 in GCF may be an inflammatory marker for periodontitis. PMID: 25740558
  78. Serum YKL-40 levels are elevated in patients with gestational diabetes mellitus but are unaffected by the oral glucose tolerance test. YKL-40 levels are related to glycated hemoglobin, fasting insulin and HOMA-IR. These results suggest that YKL-40 may be a major contributor to gestational diabetes mellitus. PMID: 26698539
  79. genetic variants on the CH13L1 locus were significantly associated with CSF YKL-40 levels, but not Alzheimer's disease risk, age at onset, or disease progression PMID: 27832767
  80. YKL-40 may be involved in the occurrence and development of diabetic nephropathy and would be useful as a new marker for the disease. PMID: 26782508
  81. Our findings suggest that CHI3L1 is induced by acute exercise and that CHI3L1/PAR-2 signalling activates myocyte proliferation PMID: 26303257
  82. Elevated serum CHI3L1 concentration is an independent prognostic biomarker for poorer survival in lung cancer patients. PMID: 26828595
  83. YKL-40 expression is up-regulated in patients with COPD and correlates with exacerbation attacks and may contribute to airway remodeling by acting on lung fibroblasts. PMID: 27013031
  84. This review comprehensively analyzes recent data about expression pattern, and involvement of human YKL-40, YKL-39 and SI-CLP in cancer. [review] PMID: 26733160
  85. Increased mRNA level of CHI3L1 could be associated with the progression of astrocytoma and poor patient survival not only for glioblastoma, but for lower grade astrocytoma tumors as well. PMID: 27121858
  86. serum YKL-40 level in coronary artery disease patients was significantly higher than that in control subjects. PMID: 27152377
  87. Study suggests that a newly identified subgroup of SSEA-4 and YKL-40 positive cells constitute a fraction of astroglial progenitors, and suggests the name SYPAP (SSEA-4 and YKL-40 positive astroglial progenitors) for this particular population PMID: 26295543
  88. Serum YKL-40 level increases with severity of obstructive sleep apnea syndrome (OSAS). The findings suggest that YKL-40 may be a useful biomarker for inflammation in patients with OSAS. PMID: 26523896
  89. CHI3L1 is expressed during the process of differentiation and maturation of dendritic cells in time dependent manner, it could play a crucial role in the dendritic cells immune response. PMID: 26466985
  90. Neurogranin and YKL-40 are promising AD biomarkers, independent of and complementary to the established core Alzheimer's disease (AD) biomarkers, reflecting additional pathological changes in the course of AD PMID: 26698298
  91. Data show that the expression of chitinase 3-like 1 (cartilage glycoprotein-39) protein (CHI3L1) was higher in cancerous tissues than in normal tissues. PMID: 26452028
  92. The serum YKL-40 cutoff to identify beta-thalassemia major patients with liver cirrhosis or heart disease was determined. PMID: 26603717
  93. We identified five new biomarkers: GDF15, osteonectin, TRAP5, TWEAK, and YKL40 as being promising markers for monitoring bone metastases. PMID: 27069189
  94. Pregnancy seems to be associated with a temporary reduction in circulating YKL-40, which increases after delivery, but to a much lesser extent in women with GDM than in non-GDM women. PMID: 26301577
  95. cerebrospinal fluid CHI3L1 and CHI3L2 and serum CHI3L1 might help to define multiple sclerosis disease stage PMID: 25698171
  96. Serum YKL-40 together with serum CTX-MMP/PINP ratio and World Health Organization status were independent predictors of time to first SRE. PMID: 25573204
  97. We also demonstrated that miR-24 suppressed the expression of chitinase 3-like 1 (CHI3L1) mRNA, thought to mediate multiple signaling pathways PMID: 25976273
  98. CHI3L1 Is a Liver-Enriched, Noninvasive Biomarker That Can Be Used to Stage and Diagnose Substantial Hepatic Fibrosis. PMID: 26415140
  99. YKL-40 is a potential marker for in vitro cultured pro-inflammatory macrophages and is not a valuable biomarker in serum and sputum of patients with COPD treated with inhaled corticosteroids. PMID: 26696093
  100. Ykl-40 expression was significantly lower in the serum of TB patients compared to lung cancer, lung metastasis, pneumonia, and transudate pleural effusion. Pleural Ykl40 was similar among all groups. PMID: 26620310

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Involvement in disease Asthma-related traits 7 (ASRT7); Schizophrenia (SCZD)
Subcellular Location Secreted, extracellular space, Cytoplasm, Cytoplasm, perinuclear region, Endoplasmic reticulum
Protein Families Glycosyl hydrolase 18 family
Tissue Specificity Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts.
Database Links

HGNC: 1932

OMIM: 181500

KEGG: hsa:1116

STRING: 9606.ENSP00000255409

UniGene: Hs.382202

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