Recombinant Human Cholinesterase(BCHE)

Code CSB-YP002604HU
Product Type Recombinant Protein
Size US$2010
Uniprot No. P06276
Relevance Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Storage Buffer Tris-based buffer,50% glycerol
Alias Acylcholine acylhydrolaseButyrylcholine esteraseCholine esterase IIPseudocholinesterase
Species Homo sapiens (Human)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCVGL
Research Area Neuroscience
Source Yeast
Gene Names BCHE
Protein Names Recommended name: Cholinesterase EC= 3.1.1.8 Alternative name(s): Acylcholine acylhydrolase Butyrylcholine esterase Choline esterase II Pseudocholinesterase
Expression Region 29-602aa
Tag Info N-terminal 6xHis-tagged
Mol. Weight 67.1kDa
Protein Description Full Length of Mature Protein
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
Involvement in disease Butyrylcholinesterase deficiency (BChE deficiency)
Subcellular Location Secreted
Protein Families Type-B carboxylesterase/lipase family
Tissue Specificity Detected in blood plasma (at protein level). Present in most cells except erythrocytes.
Database Links

HGNC: 983

OMIM: 177400

KEGG: hsa:590

STRING: 9606.ENSP00000264381

UniGene: Hs.420483

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