Recombinant Human Cyclin-related protein FAM58A (FAM58A)

Code CSB-YP843137HU
MSDS
Size Pls inquire
Source Yeast
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Code CSB-EP843137HU
MSDS
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Source E.coli
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Code CSB-EP843137HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP843137HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP843137HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
CCNQ
Uniprot No.
Alternative Names
Cyclin-M; Cyclin-related protein FAM58A; FA58A_HUMAN; Fam58a; Family with sequence similarity 58 member A; STAR
Species
Homo sapiens (Human)
Expression Region
1-248
Target Protein Sequence
MEAPEGGGGG PAARGPEGQP APEARVHFRV ARFIMEAGVK LGMRSIPIAT ACTIYHKFFC ETNLDAYDPY LIAMSSIYLA GKVEEQHLRT RDIINVSNRY FNPSGEPLEL DSRFWELRDS IVQCELLMLR VLRFQVSFQH PHKYLLHYLV SLQNWLNRHS WQRTPVAVTA WALLRDSYHG ALCLRFQAQH IAVAVLYLAL QVYGVEVPAE VEAEKPWWQV FNDDLTKPII DNIVSDLIQI YTMDTEIP
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Activating cyclin for the cyclin-associated kinase CDK10.
Gene References into Functions
  1. These ophthalmic findings are the first reported to our knowledge in association with STAR syndrome. The literature frequently demonstrates that patients with developmental anomalies often have ocular manifestations, warranting a full ophthalmic examination when the diagnosis of STAR syndrome has been made or is being considered. PMID: 26882209
  2. this is the first occurrence of a nonsense variant in FAM58A described in individuals with STAR syndrome and the phenotype in this pedigree suggests that tethered cord and hearing loss are features of STAR syndrome. PMID: 28322501
  3. Mutations in the cyclin family member FAM58A cause an X-linked dominant disorder characterized by syndactyly, telecanthus and anogenital and renal malformations. PMID: 18297069
Involvement in disease
Toe syndactyly, telecanthus, and anogenital and renal malformations (STAR)
Protein Families
Cyclin family, Cyclin-like FAM58 subfamily
Database Links

HGNC: 28434

OMIM: 300707

KEGG: hsa:92002

STRING: 9606.ENSP00000384396

UniGene: Hs.496943

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