Recombinant Human Doublecortin domain-containing protein 2 (DCDC2)

1. Worldwide distribution of the DCDC2 READ1 regulatory element and its relationship with phoneme variation across languages. PMID: 29666269
2. Downregulation of microRNA-645 suppresses breast cancer cell metastasis via targeting DCDC2 PMID: 29028086
3. By suggesting the presence of common biological processes underlying reading (dis)ability, these findings represent initial support for a generalist effect of the non-additive interdependence between READ1 and the KIAA0319 risk haplotype and can help in clinically assessing the individual risk for Developmental dyslexia. PMID: 29066855
4. Neonatal sclerosing cholangitis patients in substantial proportion harbour mutations in DCDC2. PMID: 27469900
5. Study concludes that DCDC2 deletion is not a strong risk factor for dyslexia. PMID: 28742079
6. The study corroborates the importance of rs7765678-DCDC2 among others in the aetiology of dyslexia in a German case-control cohort. PMID: 27312598
7. Study identified biallelic missense mutations or in-frame deletion in DCDC2 in children affected with neonatal sclerosi. Mutations involve highly conserved amino acids in the doublecortin domains of the protein. In cholangiocytes, DCDC2 protein is normally located in the cytoplasm and cilia, whereas in patients the mutated protein is accumulated in the cytoplasm, absent from cilia, and associated with ciliogenesis defect. PMID: 27319779
8. Developmental dyslexia genetic (DCDC2) and environmental factors (smoke and miscarriage) underlie ADHD traits supporting a potential pleiotropic effect. PMID: 27501527
9. that endogenous DYX1C1 localizes to the base of the cilium, whereas DCDC2 localizes along the entire axoneme of the cilium PMID: 27451412
10. DCDC2 Polymorphism is associated with reading disability. PMID: 27100778
11. off-target, non-immune mediated effects of the mTOR-inhibitor everolimus on the podocyte cytoskeleton might involve regulation of microtubules, revealing a potential novel role of TUBB2B and DCDC2 in glomerular podocyte development PMID: 26331477
12. This study demonstrated that DCDC2 intron 2 deletion impair illusory visual motion perception-specifically processed by the magnocellular-dorsal (M-D) stream-is impaired in children with Developmental dyslexia. PMID: 25270309
13. A nonsynonymous polymorphism in DCDC2 (corrected P = 0.002) and a noncoding variant in S100B (corrected P = 0.016) showed a significant association with spelling performance in families of German origin. PMID: 25877001
14. Our results reveal DCDC2a to be a deafness gene and a player in hair cell kinocilia and supporting cell primary cilia length regulation likely via its role in microtubule formation and stabilization. PMID: 25601850
15. the association of DCDC2 and KIAA0319 with Developmental dyslexia in Chinese population should be further validated PMID: 25230923
16. In a population carrying a deletion in the DCDC2 gene, impaired motion perception was identified in subjects with dyslexia. PMID: 26019324
17. DCDC2d is associated with altered fractional anisotropy PMID: 24926531
18. Among children exposed to low socioeconomic level, READ1 [regulatory element associated with dyslexia 1 ] genetic variant targets the worst outcome in children's attention. PMID: 25012462
19. DCDC2 interacts with the mediator of Wnt signaling dishevelled, and that DCDC2 overexpression inhibits beta-catenin-dependent Wnt signaling; central role of Wnt signaling in the pathogenesis of nephronophthisis-related ciliopathies PMID: 25557784
20. An SNP in DCDC2 (rs793842) was significantly associated with the thickness of the left temporoparietal cortex. PMID: 25339756
21. This study demonstrated the association of developmental dyslexia with rs4504469 of KIAA0319 and not with any single-nucleotide polymorphisms of DCDC2. PMID: 23677054
22. BV677278 is a regulatory element that influences reading and language skills. PMID: 23746548
23. In prostate cancer cells, DCDC2 colocalized with microtubules and promoted cell migration and resistance to the microtubule-targeting drug taxol.DCDC2 is aberrantly expressed in prostate cancers. PMID: 22733135
24. DCDC2 rs807701 might contribute significantly to dyslexia risk. PMID: 23229871
25. The results of this study found that DCDC2 gene contained polymorphisms that were significantly associated with white matter volume in the left temporo-parietal region and that white matter volume influenced reading ability. PMID: 22683091
26. Mutations in cilia co-expressed DCDC2, DYX1C1 and KIAA0319 genes are associated with a cognitive neurological disorder, dyslexia. PMID: 22558177
27. DCDC2 influences both reading and memory impairments. PMID: 21881542
28. The DCDC2 gene may not be a susceptibility factor for developmental dyslexia among the Han Chinese. PMID: 22490485
29. We provide further support for the role of KIAA0319 and DCDC2 in contributing to reading abilities PMID: 21457949
30. DCDC2 overexpression in C. elegans causes an abnormal neuronal phenotype that can only be seen in ciliated neurons. Together our results suggest a potential role for DCDC2 in the structure and function of primary cilia PMID: 21698230
31. This study demonistrated that The superior prefrontal, temporal and occipital networks were positively related to DCDC2 in the schizophrenia, but not the control group. PMID: 21507613
32. Five alleles displayed strong enhancer activity and increased gene expression, while allele 1 showed no enhancer activity. These studies suggest that the association of BV677278 with RD reflects a role as a modifier of DCDC2 expression. PMID: 21042874
33. We identified four rare variants that were significantly associated with the late MMN component. PMID: 21104116
34. No statistically significant associations were found between DCDC2 or DYX1C1 and language phenotypes. Both DCDC2 and DYX1C1 DD susceptibility genes appear to have a pleiotropic role on mathematics but not language phenotypes. PMID: 21046216
35. At this point, there is no statistical evidence of association between the allelic variation in the three candidate genes and DD in our sample. PMID: 21203818
36. DCDC2 is a risk gene for reading disorder. PMID: 20068590
37. DCDC2 is proposed as a candidate gene for reading disability. PMID: 16278297
38. Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia. PMID: 16385449
39. A slight tendency for an intronic deletion in DCDC2 to be associated with worse performance on some quantitative measures of dyslexia in the probands, was observed. PMID: 17450541
40. we found a nominally significant association for the quantitative dimension "word reading" and dcdc2 genotype PMID: 18810304
41. conclude that the causative variant/s in DCDC2 conferring susceptibility to dyslexia in our sample remain/s to be identified PMID: 19018237
42. suspected dyslexia-associated gene PMID: 19238550
43. Our data suggest that the causal variants for ADHD might be found in the VMP/DCDC2 region PMID: 19362708

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HGNC: 18141

OMIM: 600202

KEGG: hsa:51473

STRING: 9606.ENSP00000367715

UniGene: Hs.61345