Recombinant Human Estrogen-related receptor gamma (ESRRG)

1. ERRgamma may exert oncogenic activity mainly associated with aggressiveness of EC by activating S100A4 transcription. PMID: 29901152
2. Loss of ERRgamma in renal epithelial cells Results in Kidney Disease with Cysts. PMID: 29735694
3. our present results show an intriguing association between the ESRRG rs1890552 GG genotype and an increased risk of impaired fasting glucose or type 2 diabetes mellitus as well as increased oxidative stress. PMID: 28034514
4. It was also associated with beta-cell function (P=1.99 x 10(-3)) and fasting glucose level (P<0.05) in the meta-analyses of glucose and insulin-related traits consortium (MAGIC) data set.Cnoclusions:In summary, we identified epigenomic characteristics for obesity genes and suggested ESRRG as a novel obesity-susceptibility gene PMID: 27113491
5. this study elucidates a molecular mechanism linking CB1R signaling, ERRgamma expression and fibrinogen gene transcription. PMID: 28750085
6. Disruption of the orphan receptor ESRRG and disruption of KIAA0825 identified in a subject with hearing loss and mild developmental delay. Given the translocation breakpoints and supporting literature, disruption of ESRRG is the most likely cause for the disorder. PMID: 27381092
7. Data suggest that activation of ERRgamma is involved in induction of matrix metalloproteinases 2/9 (MMP2 and MMP9) and increased migration/invasiveness of triple-negative breast cancer cells caused by low concentrations of environmental endocrine disruptors (nanomolar bisphenol A used here). PMID: 27038254
8. The present results strongly suggest that human nuclear receptor ERRgamma functions as a genuine homomeric dimer with symmetrical dimeric interface regions. PMID: 26662629
9. ERRgamma overexpression directs metabolic maturation in human Induced Pluripotent Stem Cells-derived beta-like cells. PMID: 27076077
10. Estrogen-related receptor gamma is upregulated in liver cancer and its inhibition suppresses liver cancer cell proliferation via induction of p21 and p27. PMID: 26940882
11. Data show that micrRNA miR-320a directly targets cAMP-regulated phosphoprotein 19 (ARPP-19) and estrogen-related receptor gamma protein (ERRgamma) in breast cancer cell lines. PMID: 25736597
12. ERRgamma signaling is associated with poor DMFS in ER+, TAM-treated breast cancer PMID: 25971350
13. ESRRG is down-regulated in placenta from intrauterine growth restriction tissue. PMID: 26051094
14. Results suggest that hypoxia-inducible factor-1alpha can positively regulate the dopaminergic phenotype through estrogen-related receptor gamma . PMID: 25807177
15. The results reveal that the double-layer binding sites, namely, the ordinary ligand binding sites and their back support residues, substantiate the strong binding of BPA to ERRgamma. PMID: 24978476
16. A role for ESRRG in maternal blood pressure homeostasis during pregnancy. PMID: 24725083
17. Report estrogen-mediated cell kinetics and the role of oestrogen-related receptor gamma on biliary epithelial cells in the pathogenesis of primary biliary cirrhosis. PMID: 24687322
18. ERRgamma protein levels are affected by the activation state of ERK/mitogen-activated protein kinase, and mutation of consensus ERK target sites impairs ERRgamma-driven transcriptional activity and tamoxifen resistance. PMID: 24684682
19. These findings demonstrate a novel ERRgamma/GATA4 signal cascade in the development of cardiac hypertrophy. PMID: 24083978
20. Nuclear ANG directly binds to the ANG-Binding Sequence within ERRgamma of ERRgamma gene and inhibits ERRgamma transcription to promote breast cancer cell proliferation. PMID: 23977052
21. ERRGamma mediates oxygen-dependent expression of genes involved in human trophoblast differentiation, function, and vascular homeostasis. PMID: 23584901
22. Iranian women with short AAAG repeat are at higher risk of breast cancer. PMID: 24125170
23. plays a role in maintenance of hearing in both humans and mice. PMID: 23540940
24. The ESRRG gene is a novel target of miR-205 mediated RNA-interference. PMID: 23589079
25. Data show that the orphan nuclear receptor estrogen related receptor gamma (ERRgamma) plays a critical role in hypoxia-mediated activation of pyruvate dehydrogenase kinase 4 (PDK4) gene expression. PMID: 23050013
26. results suggest that Estrogen-Related Receptor gamma (ERRgamma) could be implicated in the energy metabolism regulation of human trophoblasts PMID: 22763271
27. Orphan nuclear receptor estrogen-related receptor gamma (ERRgamma) is key regulator of hepatic gluconeogenesis PMID: 22549789
28. Our study indicates that the AAAG tetranucleotide repeat polymorphism in ERR-gamma gene 5' UTR region may be a new biomarker for genetic susceptibility to breast cancer. PMID: 21153485
29. Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1alpha/ERRgamma complex PMID: 22049338
30. Estrogen-related receptor gamma (ERRgamma) is a novel transcriptional regulator of phosphatidic acid phosphatase, LIPIN1, and inhibits hepatic insulin signaling PMID: 21911493
31. These novel findings identify ERRgamma as an O(2)-dependent transcription factor and HIF-1alpha target gene that serves a critical role in the induction of hCYP19 expression during human trophoblast differentiation. PMID: 21757507
32. Study provides evidence for nuclear receptor mediated regulation of Dnmt1 expression through ERRgamma and SHP crosstalk. PMID: 21459093
33. miR-378( *) inhibits the expression of two PGC-1beta partners, ERRgamma and GABPA, leading to a reduction in TCA cycle gene expression and oxygen consumption as well as an increase in lactate production and in cell proliferation PMID: 20889127
34. Estrogen-related receptor gamma modulates cell proliferation and estrogen signaling in breast cancer. PMID: 20883782
35. These results suggest involvement of ESRRgamma in the determination of bone density in women. PMID: 19821770
36. Transcriptional activation by ERR3 can be ligand-independent. PMID: 11864604
37. Not only PNRC2 but also the corepressor TLE1 functioned as ERRgamma coactivator in a reporter gene analysis PMID: 14651967
38. Up-regulation of estrogen-related receptor gamma is associated with endometrial adenocarcinoma PMID: 16681769
39. Thermal stability studies show that agonist binding leads to global stabilization of the ligand binding domain. PMID: 16990259
40. is a novel target of ERRgamma, and their interaction is crucial for cancer cell proliferation PMID: 17706602
41. First evidence is provided that the nuclear receptor estrogen-related receptor gamma forms complexes with the endocrine disruptor, providing detailed molecular insight into the interaction features. PMID: 17761695
42. Results clearly indicate that estrogen-related receptor gamma forms an appropriate structure presumably to adopt an unidentified endogenous ligand. PMID: 18005256
43. ERRGamma (estrogen-related receptor gamma ) mRNA levels decreased from normal vagina of the pre-menopausal women to atrophic vaginal tissue in post-menopausal women PMID: 18328649
44. The 2.0 A crystal structure of the 4-alpha-cumylphenol/ERRgamma complex clearly revealed that ERRgamma's Leu345-beta-isopropyl plays a role in the tight binding of 4-alpha-cumylphenol and BPA, rotating in a back-and-forth induced-fit manner. PMID: 18582436
45. Kaempferol is an estrogen-related receptor gamma inverse agonist. PMID: 19171140
46. placenta expresses ERRgamma mRNA extremely highly; among the 3 ERRgamma protein isoforms, placenta exclusively expresses the type-1 isoform; results suggest that bisphenol A accumulates in the placenta by binding to ERRgamma PMID: 19304792
47. Single nucleotide polymorphisms in the estrogen-related receptor gamma is Associated with post-menopausal breast cancer women. PMID: 19415745
48. SMILE is a novel corepressor of ERRgamma, and SIRT1 has a role as a novel repressive mechanism for SMILE and ERRgamma inverse agonist PMID: 19690166

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HGNC: 3474

OMIM: 602969

KEGG: hsa:2104

STRING: 9606.ENSP00000386171

UniGene: Hs.444225