Recombinant Human Exophilin-5 (EXPH5), partial

Code CSB-YP843342HU
MSDS
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Source Yeast
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Code CSB-EP843342HU
MSDS
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Source E.coli
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Code CSB-EP843342HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP843342HU
MSDS
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Source Baculovirus
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Code CSB-MP843342HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
EXPH5
Uniprot No.
Alternative Names
EXPH5; KIAA0624; SLAC2BExophilin-5; Synaptotagmin-like protein homolog lacking C2 domains b; SlaC2-b; Slp homolog lacking C2 domains b
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
May act as Rab effector protein and play a role in vesicle trafficking.
Gene References into Functions
  1. Mutations in EXPH5 protein, human have been implicated in the physiopathology of Epidermolysis bullosa simplex. PMID: 27384765
  2. The results identify a further EXPH5 pedigree suggest that mutations in EXPH5 should be considered as a possible candidate gene for recessive or sporadic cases of mild generalized EBS. PMID: 26211931
  3. Here, we report the second family with two EXPH5 mutations in epidermolysis bullosa simplex. PMID: 24005056
  4. our findings identify an unexpected role for Slac2-b in inherited skin fragility and expand the clinical spectrum of human disorders of GTPase effector proteins. PMID: 23176819
  5. Slac2-b/KIAA0624 contains an N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD of Slac2-b specifically and directly binds the GTP-bound form of Rab27A (J. Biol. Chem. 277, (2002) 9212-9218; PMID: 11773082). PMID: 11773082

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Involvement in disease
Epidermolysis bullosa, non-specific, autosomal recessive (EBNS)
Tissue Specificity
Expressed in keratinocytes.
Database Links

HGNC: 30578

OMIM: 612878

KEGG: hsa:23086

STRING: 9606.ENSP00000265843

UniGene: Hs.28540

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