Recombinant Human Ficolin-3 (FCN3)

1. increased SFRP4 and ficolin-3 levels are significantly associated with gestational diabetes mellitus development and might be important risk factors for this pregnancy complication. PMID: 29491225
2. Study found the ratio of ficolin-3/adiponectin at 16-18 weeks of gestation was changed in pregnant women who subsequently developed gestational diabetes mellitus GDM, and might provide effective early predicting and screening for GDM. PMID: 28445618
3. Ficolin-3 was overexpressed in the serum of most hepatocellular carcinoma patients after Radiofrequency ablation . Ficolin-3 might be a biomarker for Radiofrequency ablation treatment efficacy and a potential target for hepatocellular carcinoma immunotherapy. PMID: 29386009
4. Serum H-ficolin levels inversely correlated with ground-glass opacity score on chest computed tomography in systemic sclerosis-interstitial lung disease (SSc-ILD) patients. H-ficolin-related innate immunity may be involved in SSc-ILD development. PMID: 28432700
5. Ficolin-3 plasma levels are associated with the presence and progression of abdominal aortic aneurysm (AAA), suggesting its potential role as a biomarker of AAA PMID: 28039962
6. results suggest that anti-ficolin-3 antibodies could be useful for the diagnosis of active nephritis in SLE patients PMID: 27631981
7. this study shows that H-ficolin may aid clearance of influenza A virus by promoting monocyte uptake of the virus, while reducing viral replication and virus-induced TNF-a responses in these cells PMID: 27856789
8. These results suggest that polymorphisms in the FCN3 gene cooperate to increase ficolin-3 concentration and that it might contribute to leprosy susceptibility by favoring Mycobacterium leprae infection. PMID: 28241035
9. subjects that were heterozygote carriers of both FCN2 + 6424 and FCN3 + 1637delC were sufficient mannan-binding lectin producers PMID: 26795763
10. in patients with systemic lupus erythematosus, there was no significant association between ficolin-1 and ficolin-3 with lupus nephritis PMID: 27981461
11. Monitoring serum H-ficolin levels was shown to be of no benefit in terms of predicting severe infection. PMID: 26377840
12. Serum levels of ficolin-2 and ficolin-3 were significantly lower in the cardiac syndrome X patients compared to controls. PMID: 27312152
13. LPS induces a tissue-specific recruitment of ficolin-3 and ficolin-1 in the lung and systemic compartment, respectively, suggesting an important role of distinct lectin complement pathway initiators in the local pulmonary and systemic host defence. PMID: 26868430
14. Lower serum ficolin-3 levels were correlated with injury severity following traumatic brain injury. PMID: 26627059
15. this study provide novel insight in the binding and complement activating capacity of the lectin pathway initiation molecules ficolin-2 and ficolin-3 towards relevant Gram-negative pathogens of pathophysiological relevance. PMID: 26074063
16. Data indicate differences in the plasma concentrations of collectin liver 1 and collectin kidney 1, M-ficolin and H-ficol in systemic lupus erythematosus (SLE) patients compared to a group of healthy controls. PMID: 26154564
17. H-ficolin participates in A. fumigatus defence through the activation of the lectin complement pathway, enhanced fungus-host interactions and modulated immune responses. PMID: 26133042
18. data suggest that high levels of the complement activating molecule H-ficolin are associated with an increased risk of future progression to microalbuminuria in patients with newly diagnosed type 1 diabetes. PMID: 25064124
19. High ficolin-3 level at the time of transplantation was an independent significant risk factor for shorter graft survival. PMID: 25222012
20. There is lack of association of serum mannose-binding lectin or ficolins with complement activation in patients with antiphospholipid antibodies. PMID: 25083730
21. This study aims to investigate whether an association exists between the ficolins that are part of the lectin complement pathway and systemic lupus erythematosus. PMID: 25069872
22. Both ficolin-3 and MASP-2 levels correlated inversely with the time from the onset of the attack of hereditary angioedema until blood sampling PMID: 25042985
23. Data show that the plasmid pETb-ficolin 3 was cloned successfully and the purity of the protein His-ficolin 3 was over 90%. PMID: 25001927
24. Data show that the expression of ficolin-3(FCN3) in ovarian cancer (OC) was inversely correlated with serum ficolin-3 and lower in comparison with controls. PMID: 23744477
25. low levels of ficolin-3 are associated with advanced heart failure and outcome. The decrease of ficolin-3 was associated with increased complement activation. PMID: 23596511
26. Increased fucosylation of ficolin 3 in plasma of the rheumatoid arthritis patients PMID: 23107985
27. Survival analyses showed that high pre-transplant serum levels of FCN3 were associated with decreased graft survival, suggesting an important role of FCN3 in the pathophysiology of kidney graft rejection PMID: 23416240
28. Data indicate that the median concentration of MASP-2/ficolin-3 complexes was 119.7 AU/ml (range: 2.9-615.5 AU/ml). PMID: 23142462
29. Both pre-term deliveries and low birth weight (independently of gestational age) were significantly associated with low H-ficolin concentrations but not with heterozygosity for the FCN3 1637delC frameshift mutation. PMID: 22226667
30. Found that a common variant of FCN3/CD164L2 is associated with hypertension in Chinese population. PMID: 22471352
31. H-ficolin has antiviral activity against influenza A virus (IAV). H-ficolin also fixes complement to a surface coated with IAV. PMID: 22851708
32. The purpose of this study was to determine whether circulating levels of ficolin-2 and ficolin-3 are altered in normal pregnancy and pre-eclampsia. PMID: 22670778
33. Cord blood MBL concentrations were significantly lower in intrauterine-growth-restriction (IUGR) cases than controls. No differences in H- and L-ficolin concentrations were observed between groups. PMID: 22082351
34. in whole serum. MASP-2 was co-purified with H-ficolin, and the purified H-ficolin.MASP-2 complex could activate complement as measured by cleavage of complement factor C4 PMID: 22238349
35. Data indicate that the deposition of both C4 and C3 showed a significant positive correlation with the serum concentration of Ficolin-3. PMID: 21085669
36. MBL-associated serine protease-3 down-regulate Ficolin-3 mediated complement activation through the lectin pathway. PMID: 19939495
37. Hakata antigen, a ficolin associated with MBL-associated serine proteases and small MBL-associated protein, activates the lectin complement pathway. PMID: 11907111
38. Hakata circulates as Hakata-MASPs complex in the blood, binds Aerococcus viridans polysaccharide and inhibits A. viridans growth PMID: 12367778
39. The X-ray structures of H-ficolin trimeric recognition domains, alone and in complex with various ligands, have been solved. PMID: 17215869
40. variations in H-ficolin appear to be of limited importance in the pathogenesis of Crohn's disease PMID: 17303612
41. Ficolin 3 mediates the clearance of late apoptotic cells, which suggests that this protein is involved in the maintenance of tissue homeostasis and might play a protective role against the development of autoimmunity. PMID: 17469142
42. Ficolin-3 has a high complement activating potential and is the only collagenase proteolytic resistant molecule among the lectin complement pathway initiators. PMID: 18006063
43. an FCN3+1637delC deletion variant disrupting the possibility for pattern recognition was detected; characterization of recombinant variant Ficolin-3 shows that homozygosity for the FCN3+1637delC deletion may lead to Ficolin-3 deficiency PMID: 18261799
44. L-ficolin residue lysine57 is a key component of the interaction with both the mannan-binding lectin (MBL)-associated serine proteases and calreticulin, providing a strong indication that MBL and ficolins share homologous binding sites for their partners. PMID: 19109177
45. Results suggest that the elevation of S-ficolin-3 and its association with specific manifestations in systemic lupus erythematosus may indicate a pathogenetic role of ficolin-3 in SLE. PMID: 19208603

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HGNC: 3625

OMIM: 604973

KEGG: hsa:8547

STRING: 9606.ENSP00000270879

UniGene: Hs.333383