Recombinant Human GDNF family receptor alpha-4 (GFRA4)

Unavailable
Code CSB-YP863936HU
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Source Yeast
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Code CSB-EP863936HU
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Source E.coli
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Code CSB-EP863936HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP863936HU
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Source Baculovirus
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Code CSB-MP863936HU
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
GFRA4
Uniprot No.
Alternative Names
GDNF family receptor alpha 4; GDNF family receptor alpha-4; GDNF receptor alpha-4; GDNFR-alpha-4; GFR alpha 4; GFR receptor alpha 4; GFR-alpha-4; GFRA4; GFRA4_HUMAN; Glial cell line derived neurotrophic factor family receptor alpha 4; Neurotrophic factor receptor splice variant A (Gfra4 gene); OTTHUMP00000030106; OTTHUMP00000030107; Persephin receptor
Species
Homo sapiens (Human)
Expression Region
21-278
Target Protein Sequence
VGGNRCVDAA EACTADARCQ RLRSEYVAQC LGRAAQGGCP RARCRRALRR FFARGPPALT HALLFCPCAG PACAERRRQT FVPSCAFSGP GPAPPSCLEP LNFCERSRVC RCARAAAGPW RGWGRGLSPA HRPPAAQASP PGLSGLVHPS AQRPRRLPAG PGRPLPARLR GPRGVPAGTA VTPNYVDNVS ARVAPWCDCG ASGNRREDCE AFRGLFTRNR CLDGAIQAFA SGWPPVLLDQ LNPQGDPEHS LLQVSSTG
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.
Gene References into Functions
  1. Results support that aberrant CpG hypermethylation at least partly accounts for GFRA4 silencing in HSCR, which impairs its protective role in enteric nervous system. PMID: 29634418
  2. High GFRA4 expression is associated with Hirschsprung's Disease. PMID: 29090971
  3. GDNF/GFRalpha1 is crucial for efficient signal transduction to recruit Ret protein into lipid rafts. PMID: 15225646
Subcellular Location
[Isoform GFRalpha4a]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform GFRalpha4b]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform GFRalpha4c]: Secreted.
Protein Families
GDNFR family
Tissue Specificity
Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.
Database Links

HGNC: 13821

KEGG: hsa:64096

STRING: 9606.ENSP00000313423

UniGene: Hs.302025

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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