Recombinant Human Glutathione peroxidase 1(GPX1)

Code CSB-YP009866HU
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Source Yeast
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Code CSB-EP009866HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP009866HU
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Source Baculovirus
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Code CSB-MP009866HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names GPX1
Uniprot No. P07203
Alternative Names AL033363; Cellular glutathione peroxidase; Glutathione peroxidase 1; Glutathione peroxidase; GPx 1; GPx-1; GPX1; GPX1_HUMAN; GPXD; GSHPx-1; GSHPX1; MGC14399; MGC88245
Species Homo sapiens (Human)
Expression Region 1-203
Target Protein Sequence MCAARLAAAA AAAQSVYAFS ARPLAGGEPV SLGSLRGKVL LIENVASLUG TTVRDYTQMN ELQRRLGPRG LVVLGFPCNQ FGHQENAKNE EILNSLKYVR PGGGFEPNFM LFEKCEVNGA GAHPLFAFLR EALPAPSDDA TALMTDPKLI TWSPVCRNDV AWNFEKFLVG PDGVPLRRYS RRFQTIDIEP DIEALLSQGP SCA
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Protects the hemoglobin in erythrocytes from oxidative breakdown.
Gene References into Functions
  1. that polymorphisms in GPX1 and GPX4 are significantly associated with episodic memory and AD in a South Brazilian population PMID: 29246792
  2. there is no correlation between idiopathic male infertility and the GPx1 codon Pro198Leu polymorphism; further studies are needed to investigate other genetic factors that influence the development of idiopathic male infertility PMID: 27028814
  3. Increased glutathione peroxidase (GPx) activity seemed to compensate for a decrease in GPx1 protein due to enhanced degradation via the proteasome. Mass spectrometry analysis identified Lys-114 as a possible carbonylation target which provides a vestibule for the substrate H2O2 and thus enhances the enzymatic reaction PMID: 29499564
  4. ESR1 and GPX1 expression levels were found to be significantly down-regulated by 14.7% and 7.4% (respectively) in the tumorous breast tissue when compared to the non-malignant one. PMID: 29543921
  5. The result of this study suggested that GPX1 Pro198Leu polymorphism could not be a risk factor for breast cancer in Rwanda. PMID: 29411539
  6. A significant increase in the T allele and TT genotype frequencies was observed in diabetic peripheral neuropathy patients compared to control diabetics. The association remained significant after correction for age, disease duration, HbA1c and BMI. PMID: 27592002
  7. No significant differences in allelic or genotypic frequencies of GPX1 rs1050450 or GSTP1 rs1695 were detected between Chinese schizophrenia cases and controls. PMID: 28872562
  8. Genetic variations in selenoprotein genes modulated both GPX1 and SELENOP selenoprotein gene expression and global gene expression in response to Brazil nut supplementation. PMID: 28696394
  9. Allele-specific interaction between GPX1 and MnSOD affects the levels of Bcl2, Sirt3 and E-cadherin. PMID: 28587495
  10. GPX1, GPX3 and GPX4 may be upregulated in response to a change in oxidative stress during an acute coronary syndromes PMID: 28298473
  11. The Pro198Leu polymorphism (rs1050450) to the selenoprotein glutathione peroxidase 1 gene (GPX1), and GSTM1 deletion had no effect on mercury levels in mildly exposed people, suggesting these genetic variants impact mercury levels only in highly exposed populations. PMID: 27450956
  12. Evaluation of Glutathione Peroxidase and KCNJ11 Gene Polymorphisms in Patients with New Onset Diabetes Mellitus After Renal Transplantation PMID: 28073131
  13. G/C (rs8179169; Arg5Pro) and T/C (rs4991448; Leu6Pro) polymorphisms significantly associated with vitiligo PMID: 26991090
  14. Data show that the inflammation of the gallbladder wall (IGW) correlated significantly with plasma GPX1 and hs-CRP (high-sensitivity C-reactive protein) values suggesting that inflammation and oxidative stress are related. PMID: 29187474
  15. High GPX1 expression is associated with oral squamous cell carcinoma. PMID: 28653098
  16. GPX1 is a gatekeeper restraining the oncogenic power of mitochondrial ROS generated by SOD2 is presented. Review. PMID: 28087256
  17. Using lens epithelial cells derived from targeted inactivation of Prdx6(-/-) gene and relative enzymatic and stability assays, we discovered dramatic increases in GSH-peroxidase (30%) and aiPLA2 (37%) activities and stability in the K122/142 R mutant, suggesting Sumo1 destabilized Prdx6 integrity PMID: 28055018
  18. Coronary angiography findings indicated that individuals possessing Pro198Leu (CT) polymorphism were found to be associated with low erythrocyte GPX-1 activity and increased susceptibility for coronary artery disease. PMID: 27229152
  19. High GPX1 expression is associated with Thyroid Tumors. PMID: 26970173
  20. Data suggest that serum myeloperoxidase (GPX1) levels are significantly associated with higher asymmetric dimethyl-arginine (ADMA) levels and up-regulation of circulating components of renin-angiotensin-aldosterone-system in patients with cardiovascular disease (CVD). Serum levels of ADMA and angiotensin II are more predictive for all-cause and CVD mortality compared to GPX1. PMID: 28322753
  21. Pro198Leu of GPX1 might be a genetic risk factor in the development of Nephrolithiasis in South Iranian patients with lower Glutathione Peroxidase enzyme activity. PMID: 28174350
  22. our data suggest that gene polymorphisms of GPX1 Pro198Leu and CAT C262T may have a protective role in the development of primary open-angle glaucoma in a Polish population. PMID: 28547970
  23. GPx-1 expression deters the unfolded protein response following exposure to cigarette smoke PMID: 28070146
  24. Knockdown of GPX1 in hucMSCs abrogated antioxidant and anti-apoptotic abilities of hucMSC-Ex and diminished the hepatoprotective effects of hucMSC-Ex in vitro and in vivo. Thus, hucMSC-Ex promote the recovery of hepatic oxidant injury through the delivery of GPX1. PMID: 28089078
  25. The potential protective effect without statistical relationships were also observed for other genotypes and alleles studied polymorphic variants of antioxidant enzymes in CD and CAT- 262C / T and + 35 A / C SOD1 in UC. Conducted our audit should be extended to more group of patients in order to assess whether or not to confirm the observed during analysis, the protective effect of CAT-262 C / T in ulcerative colitis and PMID: 28141554
  26. No significant differences in SOD and GPx activity both in plasma and saliva were found between Crohn's Disease remission group and the control group. PMID: 28011951
  27. GPX1 and SEPP1 Single Nucleotide Polymorphism were not associated with any changes in the expression of related genes. GPX1 was shown to modulate the expression of unrelated target, SEP15, upon Se supplementation, both alone and in combination with SEPP1. PMID: 26658762
  28. Study demonstrates that SOD2 rs4880, GPX1 rs1050450 and CAT rs1001179 are not associated with an increased susceptibility to epilepsy after neonatal hypoxic-ischemic encephalopathyor its drug resistance PMID: 28222320
  29. Data show that antioxidant enzymes SOD2 and GPX1 expression and GPX1 and SOD1 activity were significantly higher in patients at diagnosis of bladder cancer (BC) in comparison to controls. PMID: 28179340
  30. Data show that the placement of rectus sheath block (RSB) analgesia did not significantly affect the level of oxidative stress biomarker plasma glutathione peroxidase (GPX1) level in patients with benign disease or cancer. PMID: 28179349
  31. Adiponectin gene promoter -11377C/G (CG), -11377C/G (GG), GPx-1 gene C594T (CT), C594T (TT), and cigarette smoking are risk factors in nonalcoholic fatty liver disease (NAFLD). PMID: 26897098
  32. Our results suggest that GSTP1 rs1695 and GPX1 rs1050450 single nucleotide polymorphisms have no effect on the risk of preeclampsia in the Chinese Han population. PMID: 27825163
  33. Results show no significant association between glutathione peroxidase 1 (GPX1) Pro198Leu polymorphism and risk of bladder cancer. PMID: 28145855
  34. It was concluded that the genotype for SNPs in GPX1 and gender affected biomarkers of Se status in this pilot study with healthy Brazilians. PMID: 27164132
  35. The effects of oleuropein (OL) on hydrogen peroxide-induced oxidative stress in L02 cells showed that SOD1, GPx1, and catalase levels were all increased, and suggested that OL is a potent antioxidant and may be therapeutically useful in liver disease prevention. PMID: 27914828
  36. This meta-analysis showed a significant association between low GPx level and vitiligo. PMID: 27218102
  37. GPx-1 Pro200Leu polymorphism was associated with obesity especially with morbid obesity, but not with obese participants with prediabetes or diabetes PMID: 26545512
  38. variants of GPx1 and MnSOD should not be considered as a risk factor of laryngeal squamous cell carcinoma. PMID: 27188866
  39. Glucose oscillations may exert more deleterious effects on the endothelium than high glucose, likely due to an impaired response of glutathione peroxidase-1, coupled by the upregulation of miR-185 PMID: 27137793
  40. Results showed no statistically significant difference between the vitiligo and MnSOD Ala-9Val and GPx1 Pro198Leu gene polymorphisms in Turkish population. PMID: 27100222
  41. The purpose of the study was to evaluate the plasma level of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) and the association between polymorphic variants in genes encoding for GPx1, SOD, CAT and the risk of distal symmetric polyneuropathy in type 2 diabetes mellitus patients. PMID: 26674569
  42. This study examined the relationship between levels of GPx activity, reactive oxygen species, and platelet activation in 51 acute coronary syndrome (ACS) patients. PMID: 27993878
  43. The MnSOD, GPX1 and CAT genotypes and allele frequencies of acute kidney injury patients did not differ significantly from those of healthy controls. PMID: 26787049
  44. the presence of variant allele and genotype of GPX1 Pro198Leu and GSTP1 Ile105Val gene polymorphisms may modulate the risk of developing acute myeloid leukemia PMID: 26823947
  45. GPX1 Pro198Leu rs1050450 genotypes differentially affect the selenium status and GPx activity. PMID: 26661784
  46. patients with end-stage renal disease (ESRD) and those without chronic kidney disease (CKD) of Han Chinese origin, with SOD2 (Val16Ala), GPX1 (Pro197Leu), and PPAR-gamma (Pro12Ala, C161T) were genotyped. PMID: 26881045
  47. 1,25D3 works as a modifier of NF-kappaB/GPX1/uPA expression, inhibiting cisplatin-resistance and cell invasive ability of salivary adenoid cystic carcinoma cells PMID: 26782341
  48. SOD2 but not GPx1 activity decreased significantly in the presence of the mutated allele (Val and Leu, respectively). PMID: 27067415
  49. GPX1*Pro198Leu AND GPX3 rs2070593 as genetic risk markers for Italian asthmatic patients PMID: 26662676
  50. An increase in both SOD1 and GPx1 activity is involved in the protective effect of sulodexide on ischemic endothelial cells. PMID: 26477504
  51. In patients with chronic hepatitis C, the GPX1 Pro198Leu polymorphism, alone or combined with the CAT C-262T, was associated with high risk of fibrosis severity and hepatocellular carcinoma (HCC). In addition, GPX1 polymorphism was also associated with advanced stages of HCC. PMID: 26990426
  52. No significant difference was found for NRAMP1 and hGPX1 gene polymorphisms associated with recurrence time. PMID: 27069153
  53. Experimental and clinical data support a role for GPx-1 in the pathogenesis of inflammatory bowel disease (IBD), authors propose that GPX1 is the most relevant gene within IBD locus 12. PMID: 26355565
  54. Findings demonstrated that miR-153 overexpression decreased radioresistance and stemness of GSCs through targeting Nrf-2/GPx1/ROS pathway. PMID: 26124081
  55. Pro198Leu and OGG1 Ser326Cys polymorphisms were not associated with panic disorder (PD) risk in Turkish patients; however, a gender-specific effect of GPX1 Pro198Leu C allele may be associated with PD development PMID: 25666858
  56. GPX1 polymorphism may be an important factor modifying oxidative stress response in breast cancer subjects. PMID: 26446998
  57. GPx1 rs1800668 polymorphism does not play a major role in sensitivity-related illnesses -related oxidative stress development. PMID: 26685757
  58. The minor T-allele of rs3448 of GPX1 was associated with kidney complications (incidences of microalbuminuria, renal events and ESRD) in patients with type 1 diabetes. PMID: 26773925
  59. the ratios SOD2/catalase and SOD2/Gpx1 could be considered as potential markers during progression from tumor growth to metastasis PMID: 25866291
  60. MIF -173CC and GPX1 594TT and high-fat diet are the risk factors for ulcerative colitis. PMID: 26829742
  61. Functional roles of catalase, PRDX2 and GPX1 during oxidative stress in human erythrocytes. PMID: 25786472
  62. Data show interaction of Polymorphisms of Resistin Gene Promoter -420C/G, Glutathione Peroxidase -1 Gene Pro198Leu and Cigarette Smoking in Nonalcoholic Fatty Liver Disease PMID: 26365964
  63. SOD, CAT, and GSH-PX content in the aqueous fluid and lenses decreased significantly with increasing lenticular nucleus hardness grading PMID: 26125826
  64. GPX1, GPX3, and GPX4 genes may play a role in clear cell renal cell carcinoma cancerogenesis. PMID: 26112936
  65. Blood lead level affected ALAD but not GPx activities, and these were not modulated by polymorphisms in ALAD and GPx genes. PMID: 26275098
  66. 593C>T GPx1 SNP alone and in synergy with 47C>T SOD2 SNP has a role in the outcome of critical illness PMID: 25497738
  67. No significant associations were observed between three other polymorphisms (MnSOD Ala16Val, CAT-262C/T, GPx Pro198Leu) and HCC susceptibility in both HBV carriers and non-HBV carriers PMID: 25894370
  68. evaluation of 3 polymorphisms - SOD1 + 35A/C, SOD2 + 47C/T, and GPx + 599C/T in type 2 diabetes mellitus (T2DM)cases and healthy controls from North India; SOD2 + 47C/T and GPx1 + 599C/T were in linkage disequilibrium and individuals with this combination had a 1.273 times higher risk of developing T2DM PMID: 25283363
  69. GPX1 (Pro l98Leu) polymorphism was associated with increased risk of early occurrence of Vibration Syndrome, Hand-Arm. PMID: 26369242
  70. GPX1 genotypes were not related to phenotypic manifestations of Wilson Disease. PMID: 24517502
  71. study indicates that CAT -262T/T genotype confers less susceptibility to spontaneous abortion, while GPX1 Pro198Leu polymorphism may not be correlated with the disease PMID: 25033027
  72. In lung transplants, 3 GPX1 SNPs (rs1800668, rs9818758, rs3811699) were significantly associated with PGD. PMID: 25439478
  73. fumarate binds to and activates a reactive oxygen species scavenging enzyme glutathione peroxidase 1 PMID: 25670081
  74. Report no association between GPX1 polymorphisms and fibromyalgia syndrome. PMID: 24817295
  75. Significant differences in GPX1 but not SOD2 expression between colorectal tumor and normal tissues. PMID: 25550558
  76. GPx1 activity was not related to erythrocyte selinium concentration and hospital mortality in patients with septic shock. PMID: 24887198
  77. Selenium, selenoenzymes, oxidative stress and risk of neoplastic progression from Barrett's esophagus: results from biomarkers and genetic variants. PMID: 22715394
  78. Results obtained indicated that both primary GPx-1 sequence and cellular location have a profound impact on cellular biology and offer feasible hypotheses about how expression of distinct GPx-1 alleles can affect cancer risk. PMID: 25047527
  79. Study supports the notion that SOD and GSH-Px polymorphisms are involved in Celiac disease development, even though findings were not statistically significant. PMID: 24634124
  80. We conclude that the PON1 Q/R192 and GPX1 Pro197Leu gene polymorphisms are not important risk factors in the development of Familial Mediterranean fever. PMID: 24841661
  81. our findings indicate that PRDX6 promotes lung tumor growth via increased glutathione peroxidase and iPLA2 activities PMID: 24512906
  82. Could not find statistically significant association between MnSOD Ala-9Val and GPx1 Pro198-Leu gene polymorphisms and susceptibility to psoriasis in a Turkish population. PMID: 24212762
  83. SAH accumulation in endothelial cells can induce tRNA(Sec) hypomethylation, which alters the expression of selenoproteins such as GPx-1 to contribute to a proatherogenic endothelial phenotype. PMID: 24719327
  84. Its depletion causes protein oxidization in ATL cells. PMID: 24323765
  85. GPX1 rs17650792 (higher risk) and GPX1 rs1800668 (lower risk) were associated with advanced prostate cancer risk. PMID: 24563517
  86. Serum samples were obtained to detect the antioxidative enzymes of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase in Sixty patients with age-related cataract. PMID: 23781296
  87. Single Nucleotide Polymorphisms in the genes GPX1 (rs1050450, rs1800668 and rs3811699), TrxR2 (rs5748469), and DIO2 (rs225014) may not be significantly associated with Kashin-Beck disease in a Tibetan population. PMID: 24058403
  88. Data suggest placentas of women with type I diabetes (not gestational diabetes) exhibit oxidative stress and up-regulation of antioxidant defense system: higher glutathione peroxidase activity, higher reduced glutathione, lower oxidized glutathione. PMID: 24054539
  89. High GPX expression was associated with breast cancer. PMID: 23765060
  90. The data provide evidence that single nucleotide polymorphisms in SEPP1 and GPX1 modulate risk of breast cancer. PMID: 24039907
  91. expression of the antioxidase glutathione peroxidase 1 in pelvic support structure of pelvic organ prolapse women was decreased, which resulted in the antioxidation reduced and may induce down-regulation of transforming growth factor-beta1-CTGF pathway PMID: 24597264
  92. The rs1050450 C > T polymorphism of GPX1 is associated with the risk of bladder but not prostate cancer. PMID: 23975365
  93. GPX1 Pro198Leu polymorphism significantly increased susceptibility to bladder cancer. PMID: 24037914
  94. GPX1 and GPX3 differences may be associated with alterations in antioxidant capacity and redox regulation PMID: 23837478
  95. Methamphetamine increases oxidative stress by reducing GPx1/4 levels, and this can be reversed with addition of selenium. PMID: 23721877
  96. there is a significant relationship between Pro197Leu GSH-Px polymorphism and major depressive disorder, but not between Ala9Val MnSOD polymorphism and mood disorders PMID: 23725507
  97. GPx-1-PTP1B-PP2A axis plays a critical role in countering the inflammatory and proteolytic responses that result in lung-tissue destruction in response to cigarette smoke exposure. PMID: 23590304
  98. Results demonstrate that TFAP2C regulates the expression of GPX1, which influences the redox state and sensitivity to oxidative stress induced by peroxides. PMID: 22964634
  99. A GPX1Pro200Leu genetic polymorphism is related to reduced concentration of plasma glutathione in schizophrenic patients. PMID: 23212700
  100. Expression of GPX-1 was higher in the recurrent group PMID: 23748877

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Subcellular Location Cytoplasm
Protein Families Glutathione peroxidase family
Database Links

HGNC: 4553

OMIM: 138320

KEGG: hsa:2876

STRING: 9606.ENSP00000407375

UniGene: Hs.76686

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