Recombinant Human Hepcidin(HAMP)

Product Type Recombinant Protein
Uniprot No. P81172
Species Homo sapiens (Human)
Gene Names HAMP
Protein Names Recommended name: Hepcidin Alternative name(s): Liver-expressed antimicrobial peptide 1 Short name= LEAP-1 Putative liver tumor regressor Short name= PLTR Cleaved into the following 2 chains: 1. Hepcidin-25 Short name=
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Target Details The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.
HGNC 15598
RGD 70971
MGI 1933533
Function Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma
Involvement in disease Hemochromatosis 2B (HFE2B)
Subcellular Location Secreted
Protein Families Hepcidin family
Tissue Specificity Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland. Secreted into the urine.
Database Links

HGNC: 15598

OMIM: 606464

KEGG: hsa:57817

STRING: 9606.ENSP00000222304

UniGene: Hs.8821

Product Details for Different Expression Systems

Product Name Recombinant Human Hepcidin(HAMP),Yeast
Code CSB-YP010124HU
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence D THFPICIFCC GCCHRSKCGM CCKT
Expression Region 60-84
Protein Description Cytoplasmic domain
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Human Hepcidin(HAMP),E.coli
Code CSB-EP010124HU
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence D THFPICIFCC GCCHRSKCGM CCKT
Expression Region 60-84
Protein Description Cytoplasmic domain
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Human Hepcidin(HAMP),Baculovirus
Code CSB-BP010124HU
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence D THFPICIFCC GCCHRSKCGM CCKT
Expression Region 60-84
Protein Description Cytoplasmic domain
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Human Hepcidin(HAMP),Mammalian cell
Code CSB-MP010124HU
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence D THFPICIFCC GCCHRSKCGM CCKT
Expression Region 60-84
Protein Description Cytoplasmic domain
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

Related Products

HAMP Antibodies

HAMP Antibodies for Human

HAMP Antibodies for Homo sapiens (Human)

HAMP ELISA Kit

HAMP ELISA Kit for Homo sapiens (Human)

Most popular with customers

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

Copyright © 2007-2018 www.cusabio.com CUSABIO TECHNOLOGY LLC All Rights Reserved.