Recombinant Human Hermansky-Pudlak syndrome 3 protein (HPS3), partial

Code CSB-YP856884HU
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Source Yeast
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Code CSB-EP856884HU
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Source E.coli
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Code CSB-EP856884HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP856884HU
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Source Baculovirus
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Code CSB-MP856884HU
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
HPS3
Uniprot No.
Alternative Names
HPS3; Hermansky-Pudlak syndrome 3 protein
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Involved in early stages of melanosome biogenesis and maturation.
Gene References into Functions
  1. HPS3 mutation is associated with high hypopigmentation in Hermansky-Pudlak syndrome. PMID: 27593200
  2. Description of mutations in HPS genes that cause Hermansky-Pudlak syndrome (review) PMID: 12125811
  3. HPS4 but not HPS3 associates with HPS1 in a complex, which we term biogenesis of lysosome-related organelles complex 3 (BLOC-3) PMID: 12847290
  4. A specific subset of melanocyte proteins are aberrantly trafficked throughout the HPS-3 melanocyte and may be responsible for the reduction in melanin synthesis. PMID: 15632015
  5. HPS3 associates with clathrin, predominantly on small clathrin-containing vesicles in the perinuclear region. This association most likely occurs directly via a functional clathrin-binding domain in HPS3. PMID: 16159387
  6. mutational analysis in Ashkenazi Jews with Hermansky-Pudlak syndrome 3 PMID: 11590544

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Involvement in disease
Hermansky-Pudlak syndrome 3 (HPS3)
Subcellular Location
Cytoplasm. Cytoplasm, cytosol.
Tissue Specificity
Widely expressed. Higher levels of expression are observed in kidney, liver and placenta.
Database Links

HGNC: 15597

OMIM: 606118

KEGG: hsa:84343

STRING: 9606.ENSP00000296051

UniGene: Hs.558314

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