Recombinant Human Immunity-related GTPase family M protein (IRGM)

1. Findings suggest that ATP/GTP binding protein like 2 (AGBL2) plays a critical oncogenic role in the pathogenesis of hepatocellular carcinoma (HCC) through modulation on immunity-related GTPase family, M protein (IRGM)-regulated autophagy and aurora kinase A (Aurora A) activity. PMID: 29126912
2. The association of ATG16L1 to Crohn's disease in Iranian patients was confirmed while it was shown that the studied polymorphisms in IRGM was not associated with Crohn's disease. PMID: 29960072
3. Four haplotypes showed a frequency of > 1%, among which the haplotype C-T-A-T-G was significantly associated with chronic periodontitis PMID: 28983640
4. HCV triggers IRGM-mediated phosphorylation of the early autophagy initiator ULK1, thereby providing mechanistic insight into the role of IRGM in HCV-mediated autophagy. PMID: 28389568
5. Irgm1/IRGM participates in the polarization of M1 macrophages, is upregulated in human atheromata, and promotes development of atheroma in murine experimental atherosclerosis PMID: 27439214
6. The results confirmed that polymorphisms in NOD2 (Leu1007insC) and IRGM genes are associated with increased risk of Crohn's disease; whereas the ORMDL3 variant is associated with susceptibility to ulcerative colitis in the Lithuanian early-onset inflammatory bowel disease population. PMID: 27932194
7. IRGM rs10065172 was associated with decreased risk of tuberculosis in Asian populations, but not in African/Africa-Americans. rs4958842, rs4859843, and rs4859846, had a large protective effect in Asians, whereas rs72553867 was not associated with tuberculosis risk. PMID: 29068986
8. Polymorphisms of IRGM gene is associated with susceptibility to ankylosing spondylitis. PMID: 28031552
9. IRGM polymorphism differences between latent and active TB suggests that genetic differences in autophagy might partly affect host TB infection status. PMID: 26980495
10. IRGM functional polymorphisms and haplotypes in promoter were associated with the susceptibility to pulmonary tuberculosis in Chinese Hubei Han population. PMID: 26786655
11. In Korean children, IRGM rs1000113 and IRGM rs72553867 exhibited associations with early-onset Crohn Disease as risk loci and defense loci, respectively. PMID: 25944217
12. The study confirms IRGM rs13361189 and rs4958847 polymorphisms to be important for Crohn's disease susceptibility and phenotype modulation, in accordance with previous findings. PMID: 26066377
13. Expression of viral protein 2C enhanced IRGM promoter activation, thereby increasing IRGM expression and inducing autophagy. PMID: 25853521
14. these data reveal an Irgm1-dependent mechanism that promotes the tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1-dependent autophagy PMID: 25619828
15. the IRGM(+313), an autophagy-related polymorphic locus, influences outcome in severely septic patients, with the possible involvement of autophagy in sepsis exacerbation PMID: 24626347
16. Results show association of IRGM gene SNPs with Crohn's disease in Indian patients and report a new mutation rs 9637876 in the IRGM gene associated with Crohn's disease. PMID: 25191865
17. Our findings suggest that expression of IRGM is dysregulated in gastric cancer and that the molecule may affect progression of the disease. PMID: 25707354
18. The IRGM rs13361189 polymorphism is promising as a biomarker for early diagnosis of Crohn's disease. However, the IRGM rs10065172 and rs4958847 polymorphisms may not be the major determinants of Crohn's disease risk. PMID: 25526194
19. Data indicate that immunity-related GTPase family M (IRGM) plays a direct role in organizing the core autophagy machinery to endow it with antimicrobial and anti-inflammatory functions. PMID: 25891078
20. RGM directly organizes the core autophagy machinery and links it with antimicrobial and anti-inflammatory functions. IRGM interacts with ULK1 and Beclin 1 promoting their co-assembly into autophagy initiation complexes. All three Crohn's disease risk factors, IRGM, NOD2 and ATG16L1, form a complex. NOD2 enhances K63-polyubiquitination of IRGM, promoting IRGM assembly with core autophagy regulators. PMID: 25891078
21. IRGM assembles core autophagy machinery (Beclin 1, Ulk1, ATG16L1) and connects it with innate immunity sensors (NOD2) through formation of protein complex assemblies. PMID: 25891078
22. This is the first study to identify a significant association between the IRGM single-nucleotide polymorphism (SNP) rs10065172 and susceptibility to active tuberculosis disease in an Asian population. PMID: 24595493
23. IRGM expression is upregulated in monocytes and monocyte-derived macrophages by Mycobacterium leprae PMID: 24469081
24. the presence of the IRGM1 rs13361189 variant allele was associated with a lower use of immunosuppressant therapy, high-lighting a possible role in the development of a milder phenotype. PMID: 24656308
25. a potential role of IRGM in the development of glioma probably by affecting IFN-gamma and IL-4. PMID: 24859836
26. Despite moderate effects on the modulation of proinflammatory cytokine production, genetic variation in the autophagy genes ATG16L1 and IRGM has a minor impact on the susceptibility to both mucosal and systemic Candida infections. PMID: 24713404
27. IRGM gene polymorphism is associated with the increased risk of leprosy by affecting inflammatory cytokines. PMID: 24264476
28. These results indicated that autophagy gene-IRGM polymorphisms appear to confer susceptibility to CD but not UC, especially in Europeans. PMID: 24232856
29. IRGM single nucleotide polymorphisms are associated with Crohn's disease. PMID: 22508677
30. In a Portuguese population, SNPs at three autophagy-related genes, ATG16L1, IRGM, and ITLN1, contribute to predict Crohn's ileal or ileocolonic disease, involvement of the upper digestive tract, and response to treatment. PMID: 22573572
31. IRGM is a susceptibility gene for Crohn's disease in the German population. PMID: 23365659
32. IRGM polymorphisms are associated with decreased susceptibility to pulmonary tuberculosis. PMID: 23049477
33. IRGM rs4958847 polymorphism influences susceptibility to gastric cancer, mainly for the intestinal type. PMID: 22713085
34. Variants in the genes ATG16L1 and IRGM affect autophagy and are associated with the development of Crohn's disease PMID: 22370477
35. IFN-gamma enhances Con A-induced autophagic flux and causes an IRGM1-dependent lysosome-mediated necrotic cell death in hepatocytes PMID: 22163006
36. Irgm3 relieves the ER stress response via a PI3K/Akt dependent mechanism, which contributes to host defence against coxsackievirus B3 infection. PMID: 21981022
37. Our work reveals an unexpected role of IRGM in virus-induced autophagy PMID: 22174682
38. Single-nucleotide polymorphism rs4958847 in the IRGM gene correlated very significantly with frequency of surgery in patients with ileocolonic Crohn's disease. PMID: 22228152
39. a critical "menage a trois" in risk susceptibility to Crohn disease combining IRGM allele, miRNA and xenophagy PMID: 21508684
40. this Crohn's Disease-related IRGM1 polymorphic allele is also associated with human susceptibility to tuberculosis disease among African Americans PMID: 21283700
41. Data show that an additive gene-gene interaction involving TLR4, PSMG1, TNFRSF6B and IRGM was identified with CD. PMID: 21079743
42. the unusual evolutionary history of the IRGM locus and the important role of the IRGM gene in autophagy and Crohn's disease in response to pathogenesis. PMID: 20737271
43. Data suggest that NKX2-3 and IRGM are susceptibility loci for inflammatory bowel disease in Eastern European patients. PMID: 21049557
44. In 1.7 kb IRGM promoter region, only -1208A/G polymorphism is associated with susceptibility to TB PMID: 20547146
45. IRGM demonstrated differential affinity for the mitochondrial lipid cardiolipin, translocated to mitochondria, affected mitochondrial fission and induced autophagy. PMID: 21102437
46. Observational study of gene-disease association. (HuGE Navigator) PMID: 19760754
47. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20886065
48. Observational study of gene-disease association. (HuGE Navigator) PMID: 20962850
49. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 21049557
50. Observational study of gene-disease association. (HuGE Navigator) PMID: 21072187

Show More

Hide All

HGNC: 29597

OMIM: 608212

KEGG: hsa:345611

STRING: 9606.ENSP00000428220

UniGene: Hs.519680